TRPV2: A Cancer Biomarker and Potential Therapeutic Target
Joint Authors
Steinhoff, Martin
Siveen, Kodappully S.
Nizamuddin, Parveen B.
Uddin, Shahab
Al-Thani, Mohamed
Frenneaux, Michael Paul
Janahi, Ibrahim A.
Azizi, Fouad
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Transient Receptor Potential Vanilloid type-2 (TRPV2) channel exhibits oncogenicity in different types of cancers.
TRPV2 is implicated in signaling pathways that mediate cell survival, proliferation, and metastasis.
In leukemia and bladder cancer, the oncogenic activity of TRPV2 was linked to alteration of its expression profile.
In multiple myeloma patients, TRPV2 overexpression correlated with bone tissue damage and poor prognosis.
In prostate cancer, TRPV2 overexpression was associated with the castration-resistant phenotype and metastasis.
Loss or inactivation of TRPV2 promoted glioblastoma cell proliferation and increased resistance to CD95-induced apoptotic cell death.
TRPV2 overexpression was associated with high relapse-free survival in triple-negative breast cancer, whereas the opposite was found in patients with esophageal squamous cell carcinoma or gastric cancer.
Another link was found between TRPV2 expression and either drug-induced cytotoxicity or stemness of liver cancer.
Overall, these findings validate TRPV2 as a prime candidate for cancer biomarker and future therapeutic target.
American Psychological Association (APA)
Siveen, Kodappully S.& Nizamuddin, Parveen B.& Uddin, Shahab& Al-Thani, Mohamed& Frenneaux, Michael Paul& Janahi, Ibrahim A.…[et al.]. 2020. TRPV2: A Cancer Biomarker and Potential Therapeutic Target. Disease Markers،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1154187
Modern Language Association (MLA)
Siveen, Kodappully S.…[et al.]. TRPV2: A Cancer Biomarker and Potential Therapeutic Target. Disease Markers No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1154187
American Medical Association (AMA)
Siveen, Kodappully S.& Nizamuddin, Parveen B.& Uddin, Shahab& Al-Thani, Mohamed& Frenneaux, Michael Paul& Janahi, Ibrahim A.…[et al.]. TRPV2: A Cancer Biomarker and Potential Therapeutic Target. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1154187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154187