Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NOcGMPATP-Sensitive-K+ Channel Activation Dependent
Joint Authors
Mbiantcha, M.
Ateufack, G.
Yousseu Nana, William
Ngouonpe Wembe, Alain
Dawe, Amadou
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Boswellia dalzielii (B.
dalzielii) is traditionally used in the treatment of rheumatism, pain, and inflammation.
The present investigation evaluates the property and possible mechanism of action of the methanolic extract of B.
dalzielii (BDME) on inflammatory and neuropathic pain models.
Effects of BDME (250 and 500 mg/kg), orally administered, were verified in mechanical hypernociception induced by LPS or PGE2.
Mechanical hyperalgesia, cold allodynia, and heat hyperalgesia were used in vincristine-induced neuropathic pain.
NW-nitro-L-arginine methyl ester (inhibitor of nitric oxide synthase), glibenclamide (ATP-sensitive potassium channel blocker), methylene blue (cGMP blocker), or naloxone (opioid antagonist receptor) has been used to evaluate the therapeutic effects of BDME on PGE2-induced hyperalgesia.
Chemical profile of BDME was determined by using HPLC-XESI-PDA/MS.
BDME showed significant antinociceptive effects in inflammatory pain caused by LPS and PGE2.
The extract also significantly inhibited neuropathic pain induced by vincristine.
The antinociceptive property of BDME in PGE2 model was significantly blocked by L-NAME, glibenclamide, methylene blue, or naloxone.
The present work reveals the antinociceptive activities of BDME both in inflammatory and in neuropathic models of pain.
This plant extract may be acting firstly by binding to opioid receptors and secondly by activating the NO/cGMP/ATP-sensitive-K+ channel pathway.
American Psychological Association (APA)
Mbiantcha, M.& Ngouonpe Wembe, Alain& Dawe, Amadou& Yousseu Nana, William& Ateufack, G.. 2017. Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NOcGMPATP-Sensitive-K+ Channel Activation Dependent. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154274
Modern Language Association (MLA)
Mbiantcha, M.…[et al.]. Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NOcGMPATP-Sensitive-K+ Channel Activation Dependent. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154274
American Medical Association (AMA)
Mbiantcha, M.& Ngouonpe Wembe, Alain& Dawe, Amadou& Yousseu Nana, William& Ateufack, G.. Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NOcGMPATP-Sensitive-K+ Channel Activation Dependent. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154274