Role of Cholinergic Anti-Inflammatory Pathway in Treatment of Intestinal Ischemia-Reperfusion Injury by Electroacupuncture at Zusanli
Joint Authors
Geng, Yanxia
Chen, Dong
Zhou, Jiang
Jiang, Hua
Zhang, Haidong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Electroacupuncture (EA) at Zusanli is a widely used method for the treatment of intestinal ischemic disease.
The current study attempts to investigate the possible mechanism from the point of cholinergic anti-inflammatory pathway (CAP) in rats.
Thirty rats were divided into five groups: control group, I/R group, EA group (I/R + EA), PNU group (I/R + α7 nAChR agonist), and α-BGT group (I/R + EA + α7 nAChR antagonist).
EA and medicine injection were performed immediately after ischemia.
After 2 h of reperfusion, blood and intestine samples were collected and intestinal histopathological score, mRNA expression of mucosal α7 nAChR and NF-κBp65, and serum cytokine levels (IL-6, TNF-α) were examined.
Compared with the I/R group, the EA group and PNU group could significantly attenuate the mucosal damage, promote α7 nAChR mRNA expression, and reduce levels of NF-κBp65, IL-6, and TNF-α.
Compared with the EA group, α7 nAChR mRNA was decreased, while concentrations of NF-κBp65, IL-6, and TNF-α increased in the α-BGT group.
EA at Zusanli could inhibit NF-κBp65 and proinflammatory cytokines production after intestinal I/R injury; its mechanism may be related to the cholinergic anti-inflammatory pathway.
American Psychological Association (APA)
Geng, Yanxia& Chen, Dong& Zhou, Jiang& Jiang, Hua& Zhang, Haidong. 2017. Role of Cholinergic Anti-Inflammatory Pathway in Treatment of Intestinal Ischemia-Reperfusion Injury by Electroacupuncture at Zusanli. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1154341
Modern Language Association (MLA)
Geng, Yanxia…[et al.]. Role of Cholinergic Anti-Inflammatory Pathway in Treatment of Intestinal Ischemia-Reperfusion Injury by Electroacupuncture at Zusanli. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1154341
American Medical Association (AMA)
Geng, Yanxia& Chen, Dong& Zhou, Jiang& Jiang, Hua& Zhang, Haidong. Role of Cholinergic Anti-Inflammatory Pathway in Treatment of Intestinal Ischemia-Reperfusion Injury by Electroacupuncture at Zusanli. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1154341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154341