Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4NF-κB and MAPK Signaling

Joint Authors

Tang, Yong-Jun
Huang, Wei-Hua
Song, Qianqian
Zheng, Xiangrong
He, Ruohui
Liu, Jie

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-08-15

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Asthma is a chronic inflammatory disease of the airways, with complex signaling pathways involved in its pathogenesis.

It was reported that paeonol attenuated airway inflammation of ovalbumin (OVA)-induced mice.

Therefore, it is of importance to further investigate the underlying mechanism.

BALB/c mice were challenged with OVA for the asthma model, which was validated by the changed levels of IL-4, IFN-γ, and IgE.

The elevation of IL-4 and the decreasing of IFN-γ were significantly in middle (p<0.05) or high (p<0.01) paeonol dose groups compared with OVA group.

MIP-1β in bronchoalveolar lavage fluid (BALF) also decreased significantly in middle and high paeonol group compared with OVA group (p<0.01), which is similar to the change of its mRNA in lung tissues.

Moreover, the inflammatory cells infiltration and collagen deposition were attenuated by paeonol and montelukast sodium via histology examination.

At last the immune blot of the protein extracted from lung tissues demonstrated that paeonol decreased the expression of TLR4 and the nuclear translocation of NF-κB, as well as the phosphorylation levels of P38 and ERK in asthma model.

In conclusion, paeonol ameliorated OVA-induced asthma through the TLR4/NF-κB and mitogen-activated protein kinase (MAPK) signaling.

American Psychological Association (APA)

Tang, Yong-Jun& Huang, Wei-Hua& Song, Qianqian& Zheng, Xiangrong& He, Ruohui& Liu, Jie. 2018. Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4NF-κB and MAPK Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154759

Modern Language Association (MLA)

Tang, Yong-Jun…[et al.]. Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4NF-κB and MAPK Signaling. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154759

American Medical Association (AMA)

Tang, Yong-Jun& Huang, Wei-Hua& Song, Qianqian& Zheng, Xiangrong& He, Ruohui& Liu, Jie. Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4NF-κB and MAPK Signaling. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154759

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1154759