Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model
Joint Authors
Yoon, Deok Hyo
Kim, Jong-Hoon
Aravinthan, Adithan
Lee, Tae Ho
Baek, Nam Joon
Kim, Tae Woong
Cho, Jae Youl
Hong, Sungyoul
Park, Jae Gwang
Sung, Gi-Ho
Son, Young-Jin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cordyceps militaris is used widely as a traditional medicine in East Asia.
Although a few studies have attempted to elucidate the anticancer activities of C.
militaris, the precise mechanism of C.
militaris therapeutic effects is not fully understood.
We examined the anticancer activities of C.
militaris ethanolic extract (Cm-EE) and its cellular and molecular mechanisms.
For this purpose, a xenograft mouse model bearing murine T cell lymphoma (RMA) cell-derived cancers was established to investigate in vivo anticancer mechanisms.
MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay, immunoblotting analysis, and flow cytometric assay were employed to check in vitro cytotoxicity, molecular targets, and proapoptotic action of Cm-EE.
Interestingly, cancer sizes and mass were reduced in a C.
militaris-administered group.
Levels of the phosphorylated forms of p85 and AKT were clearly decreased in the group administered with Cm-EE.
This result indicated that levels of phosphoglycogen synthase kinase 3β (p-GSK3β) and cleaved caspase-3 were increased with orally administered Cm-EE.
In addition, Cm-EE directly inhibited the viability of cultured RMA cells and C6 glioma cells.
The number of proapoptotic cells was significantly increased in a Cm-EE treated group compared with a control group.
Our results suggested that C.
militaris might be able to inhibit cancer growth through regulation of p85/AKT-dependent or GSK3β-related caspase-3-dependent apoptosis.
American Psychological Association (APA)
Park, Jae Gwang& Son, Young-Jin& Lee, Tae Ho& Baek, Nam Joon& Yoon, Deok Hyo& Kim, Tae Woong…[et al.]. 2017. Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154776
Modern Language Association (MLA)
Park, Jae Gwang…[et al.]. Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1154776
American Medical Association (AMA)
Park, Jae Gwang& Son, Young-Jin& Lee, Tae Ho& Baek, Nam Joon& Yoon, Deok Hyo& Kim, Tae Woong…[et al.]. Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154776