Comparative Pharmacokinetics of Geniposidic Acid, Genipin-1-β-Gentiobioside, Geniposide, Genipin, and Crocetin in Rats after Oral Administration of Crude Gardeniae Fructus and Its Three Processed Products Using LC-MSMS
Joint Authors
Chang, Yanxu
He, Jun
Yang, Xuejing
Li, Jin
Yang, Xi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The extract of Gardeniae Fructus (GF) with different processing methods processed the different medicinal properties and efficacy.
Crude GF (CGF) could be processed into stir-frying GF (SGF), gancao mix-frying GF (GCGF), and ginger mix-frying GF (GIGF) in practice.
An LC-MS/MS method was established for simultaneous quantification of geniposidic acid, geniposide, genipin-1-β-gentiobioside, genipin, and crocetin in the rat plasma.
The LLOQs for determination of all five components were 10 ng/mL.
The accuracies of intraday and interday were in the range of 91%–105%.
The recoveries of 5 analytes ranged from 81.0% to 114% with RSD less than 14%.
The results showed that the AUCs (area under the plasma concentration-time curve) and Cmax (maximum plasma concentration) of geniposidic acid, genipin-1-β-gentiobioside, and geniposide after oral administration of the CGF extract were apparently higher than those after oral administration of other processed extracts.
Cmax of geniposide in plasma after administration of GIGF significantly decreased (p<0.01).
Genipin was not detected in rat plasma after administration of the GIGF extract, but it can be detected in plasma after administration of CGF, SGF, and GCGF extract.
Furthermore, crocin I and crocin II were not detected in plasma samples.
Crocetin had higher concentration in rat plasma versus lower contents in extract.
It was demonstrated that the different processing methods might influence the pharmacokinetics of geniposidic acid, genipin-1-β-gentiobioside, geniposide, genipin, and crocetin.
American Psychological Association (APA)
Yang, Xuejing& Li, Jin& Yang, Xi& He, Jun& Chang, Yanxu. 2020. Comparative Pharmacokinetics of Geniposidic Acid, Genipin-1-β-Gentiobioside, Geniposide, Genipin, and Crocetin in Rats after Oral Administration of Crude Gardeniae Fructus and Its Three Processed Products Using LC-MSMS. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154901
Modern Language Association (MLA)
Yang, Xuejing…[et al.]. Comparative Pharmacokinetics of Geniposidic Acid, Genipin-1-β-Gentiobioside, Geniposide, Genipin, and Crocetin in Rats after Oral Administration of Crude Gardeniae Fructus and Its Three Processed Products Using LC-MSMS. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1154901
American Medical Association (AMA)
Yang, Xuejing& Li, Jin& Yang, Xi& He, Jun& Chang, Yanxu. Comparative Pharmacokinetics of Geniposidic Acid, Genipin-1-β-Gentiobioside, Geniposide, Genipin, and Crocetin in Rats after Oral Administration of Crude Gardeniae Fructus and Its Three Processed Products Using LC-MSMS. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154901