Antioxidative and Anti-Inflammatory Effects of Water Extract of Acrostichum aureum Linn. against Ethanol-Induced Gastric Ulcer in Rats
Joint Authors
Su, Zi-Ren
Liu, Yu-Hong
Luo, Dandan
Gao, Changjun
Zhang, Qian
Cai, Jian
Huang, Qiong-Hui
Wu, Xue
Xu, Nan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Acrostichum aureum Linn., a medicinal pteridophyte growing in mangrove forests and coastal regions of tropical and subtropical areas worldwide, has been proved to possess various biological effects.
However, the protective effect of Acrostichum aureum Linn.
against gastric ulcer still remains unidentified.
Therefore, the gastroprotective effect of the water extract of Acrostichum aureum Linn.
(WEAC) was investigated in ethanol-induced gastric injury model.
According to our results, pretreatment with WEAC (100, 200, and 400 mg/kg) could dramatically decrease the ulcer areas and ameliorate the pathological damage induced by alcohol in rat’s gastric tissues.
In addition, WEAC administration prevented the stomach from oxidative damage via markedly increasing the levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and decreasing the malondialdehyde (MDA).
Besides, WEAC pretreatment alleviated inflammatory infiltration by reducing the secretion of proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as decreasing the protein expressions of phosphorylation of IκBα and p65.
Taken together, WEAC exerted potential therapeutic efficacy for gastric ulceration, and this may be involved in the suppression of oxidative stress and inflammatory response.
American Psychological Association (APA)
Wu, Xue& Huang, Qiong-Hui& Xu, Nan& Cai, Jian& Luo, Dandan& Zhang, Qian…[et al.]. 2018. Antioxidative and Anti-Inflammatory Effects of Water Extract of Acrostichum aureum Linn. against Ethanol-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154902
Modern Language Association (MLA)
Wu, Xue…[et al.]. Antioxidative and Anti-Inflammatory Effects of Water Extract of Acrostichum aureum Linn. against Ethanol-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154902
American Medical Association (AMA)
Wu, Xue& Huang, Qiong-Hui& Xu, Nan& Cai, Jian& Luo, Dandan& Zhang, Qian…[et al.]. Antioxidative and Anti-Inflammatory Effects of Water Extract of Acrostichum aureum Linn. against Ethanol-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154902