Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models
Joint Authors
Cho, Hyun-Jong
Lee, Song Yi
Nam, Suyeong
Kim, Sungyun
Koo, Ja Seong
Hong, In Kee
Kim, Hill
Han, Sangin
Kang, Minji
Yang, Heejung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy.
Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities.
Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions.
The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model.
In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower than those of the other groups on day 4 (p < 0.05).
The results of the hematoxylin and eosin staining of skin tissues revealed that the epidermal thickness value of the IMQ + ACE cream group was significantly lower than those of the other experimental groups (p < 0.05).
The expression level of intracellular adhesion molecule-1 (ICAM-1), which indicates the leukocyte infiltration into the skin and subsequent interactions with keratinocytes, was also lower in the IMQ + ACE cream group than in the IMQ group.
These results indicate that ACE cream formulation could be used safely and conveniently for psoriasis treatment.
American Psychological Association (APA)
Lee, Song Yi& Nam, Suyeong& Kim, Sungyun& Koo, Ja Seong& Hong, In Kee& Kim, Hill…[et al.]. 2018. Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154928
Modern Language Association (MLA)
Lee, Song Yi…[et al.]. Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154928
American Medical Association (AMA)
Lee, Song Yi& Nam, Suyeong& Kim, Sungyun& Koo, Ja Seong& Hong, In Kee& Kim, Hill…[et al.]. Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154928