Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models
Joint Authors
Tékus, V.
Borbély, É.
Kiss, T.
Perkecz, A.
Kemény, Á.
Horváth, J.
Kvarda, A.
Pintér, E.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Arthritic diseases are the most frequent causes of chronic pain and disability.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and progressive structural joint damage.
Osteoarthritis is a degenerative process of the articular cartilage associated with hypertrophic changes in the bone.
The aim of the present study was to investigate the anti-inflammatory and analgesic effects of Hévíz thermal water and mud in monosodium iodoacetate- (MIA-) (25 mg/ml, 20 μl i.a.) induced osteoarthritis and Complete Freund’s adjuvant- (CFA-) (1 mg/ml, 50–50 μl s.c) induced rheumatoid arthritis murine models.
The mechanonociceptive threshold of female NMRI mice (n=6– 8 mice/ group) was measured by aesthesiometry, and paw volume was monitored with plethysmometry, knee joint diameter with digital micrometer, and dynamic weight bearing on the hind limbs with a Bioseb instrument.
Periarticular bone destruction was assessed by SkyScan 1176 in vivo micro-CT.
Inflammatory cytokines were detected by ELISA in plasma samples.
Treatments (30 min, every working day) with tap water, sand, and a combined therapy of tap water and sand served as controls.
Hévíz medicinal water and combined treatment with water and mud significantly decreased the mechanical hyperalgesia and knee oedema in MIA-induced osteoarthritis model.
However, balneotherapy did not influence mechanical hyperalgesia, weight bearing, or oedema formation induced by CFA.
Neither medicinal water nor mud treatment ameliorated deep structural damage of the bones or the joints in the animal models.
On the basis of the present findings, we conclude that balneotherapy is an effective complementary treatment to reduce the pain sensation and swelling in degenerative joint diseases such as osteoarthritis.
Our experimental data are in agreement with the previous human studies that also confirmed antinociceptive and anti-inflammatory effects of thermal water and Hévíz mud treatments.
American Psychological Association (APA)
Tékus, V.& Borbély, É.& Kiss, T.& Perkecz, A.& Kemény, Á.& Horváth, J.…[et al.]. 2018. Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1155297
Modern Language Association (MLA)
Tékus, V.…[et al.]. Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1155297
American Medical Association (AMA)
Tékus, V.& Borbély, É.& Kiss, T.& Perkecz, A.& Kemény, Á.& Horváth, J.…[et al.]. Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1155297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155297