Bioinformatic and Metabolomic Analysis Reveal Intervention Effects of Chicory in a Quail Model of Hyperuricemia
Joint Authors
Lin, Zhi-Jian
Zhang, Bing
Bian, Meng
Wang, Yu
Li, Gaoxi
Wang, Haige
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Hyperuricemia (HUA) is a kind of a metabolic disease that seriously threatens human health worldwide.
Chicory, a natural herbal medicine, has an obvious effect of reducing uric acid.
The aim of this study is to explore the potential components and pharmacological pathways that may play a role in hypouricemia activity of chicory.
Bioinformatics and metabonomics were applied to this research.
Firstly, component-target network was used to identify possible components related to the pharmacological properties and their corresponding mechanisms pathway of chicory.
Afterwards, animal pharmacodynamic experiments were performed.
Blood and stool samples were collected for untargeted metabolomic analysis by dint of UHPLC-Q-TOF/MS methods, and principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were performed for the pattern recognition and characteristic metabolites identification.
Significant enriched function pathways were used in bioinformatics suggesting that chicory might have the effect of regulation of lipolysis in adipocytes.
PLS-DA analysis was applied to discover differentiating metabolites, and pathway enrichment analysis indicated that chicory had powerful effects of glycosylphosphatidylinositol- (GPI-) anchor biosynthesis, inositol phosphate metabolism, glycerophospholipid metabolism, and steroid hormone biosynthesis.
Combining bioinformatics and metabolomics results, we consider that chicory may develop on lowering uric acid by adjusting lipid metabolism.
In addition, we chose quail as animal model innovatively and discussed the treatment of hyperuricemia with chicory in multiple methods, which may render reference for the research of HUA.
American Psychological Association (APA)
Bian, Meng& Lin, Zhi-Jian& Wang, Yu& Zhang, Bing& Li, Gaoxi& Wang, Haige. 2018. Bioinformatic and Metabolomic Analysis Reveal Intervention Effects of Chicory in a Quail Model of Hyperuricemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1155605
Modern Language Association (MLA)
Bian, Meng…[et al.]. Bioinformatic and Metabolomic Analysis Reveal Intervention Effects of Chicory in a Quail Model of Hyperuricemia. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1155605
American Medical Association (AMA)
Bian, Meng& Lin, Zhi-Jian& Wang, Yu& Zhang, Bing& Li, Gaoxi& Wang, Haige. Bioinformatic and Metabolomic Analysis Reveal Intervention Effects of Chicory in a Quail Model of Hyperuricemia. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1155605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155605