Thiazole Based Carbohydrazide Derivatives as α-Amylase Inhibitor and Their Molecular Docking Study
Joint Authors
Ismail, Nor Hadiani
Chigurupati, Sridevi
Taha, Muhammad
Irshad, Maryam
Imran, Syahrul
Rahim, Fazal
Selvaraj, Manikandan
Almandil, Noor Barak
Mosaddik, Ashik
Nawaz, Faisal
Ibrahim, Mohamed
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In this study we are going to present thiazole based carbohydrazide in search of potent antidiabetic agent as α-amylase inhibitors.
Thiazole based carbohydrazide derivatives 1-25 have been synthesized, characterized by 1HNMR, 13CNMR, and EI-MS, and evaluated for α-amylase inhibition.
Except compound 11 all analogs showed α-amylase inhibitory activity with IC50 values from 1.709 ± 0.12 to 3.049 ± 0.25 μM against the standard acarbose (IC50 = 1.637 ± 0.153 μM).
Compounds 1, 10, 14, and 20 exhibited outstanding inhibitory potential with IC50 value 1.763 ± 0.03, 1.747 ± 0.20, 1.709 ± 0.12, and 1.948 ± 0.23 μM, respectively, compared with the standard acarbose.
Structure activity relationships have been established for the active compounds.
To get an idea about the binding interaction of the compounds, molecular docking studies were done.
American Psychological Association (APA)
Taha, Muhammad& Irshad, Maryam& Imran, Syahrul& Rahim, Fazal& Selvaraj, Manikandan& Almandil, Noor Barak…[et al.]. 2019. Thiazole Based Carbohydrazide Derivatives as α-Amylase Inhibitor and Their Molecular Docking Study. Heteroatom Chemistry،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1155661
Modern Language Association (MLA)
Taha, Muhammad…[et al.]. Thiazole Based Carbohydrazide Derivatives as α-Amylase Inhibitor and Their Molecular Docking Study. Heteroatom Chemistry No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1155661
American Medical Association (AMA)
Taha, Muhammad& Irshad, Maryam& Imran, Syahrul& Rahim, Fazal& Selvaraj, Manikandan& Almandil, Noor Barak…[et al.]. Thiazole Based Carbohydrazide Derivatives as α-Amylase Inhibitor and Their Molecular Docking Study. Heteroatom Chemistry. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1155661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155661
