Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans
Joint Authors
Ma, Tonghui
Yang, Longfei
Liu, Xin
Feng, Xuechao
Zhong, Lili
Zhuang, Xinming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Candida albicans is the most common fungal pathogen causing serious diseases, while there are only a paucity of antifungal drugs.
Therefore, the present study was performed to investigate the antifungal effects of saponin extract from rhizomes of Dioscorea panthaica Prain et Burk (Huangshanyao Saponin extract, HSE) against C.
albicans.
HSE inhibits the planktonic growth and biofilm formation and development of C.
albicans.
16–64 μg/mL of HSE could inhibit adhesion to polystyrene surfaces, transition from yeast to filamentous growth, and production of secreted phospholipase and could also induce endogenous reactive oxygen species (ROS) production and disrupt cell membrane in planktonic cells.
Inhibitory activities against extracellular exopolysaccharide (EPS) production and ROS production in preformed biofilms could be inhibited by 64–256 μg/mL of HSE.
Cytotoxicity against human Chang’s liver cells is low, with a half maximal inhibitory concentration (IC50) of about 256 μg/mL.
In sum, our study suggested that HSE might be used as a potential antifungal therapeutic against C.
albicans.
American Psychological Association (APA)
Yang, Longfei& Liu, Xin& Zhuang, Xinming& Feng, Xuechao& Zhong, Lili& Ma, Tonghui. 2018. Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1155761
Modern Language Association (MLA)
Yang, Longfei…[et al.]. Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1155761
American Medical Association (AMA)
Yang, Longfei& Liu, Xin& Zhuang, Xinming& Feng, Xuechao& Zhong, Lili& Ma, Tonghui. Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1155761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155761