The Determination of Parkinson’s Drugs in Human Urine by Applying Chemometric Methods
Author
Source
International Journal of Analytical Chemistry
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The spectrophotometric-chemometric analysis of levodopa and carbidopa that are used for Parkinson’s disease was analyzed without any prior reservation.
Parkinson’s drugs in the urine sample of a healthy person (never used drugs in his life) were analyzed at the same time spectrophotometrically.
The chemometric methods used were partial least squares regression (PLS) and principal component regression (PCR).
PLS and PCR were successfully applied as chemometric determination of levodopa and carbidopa in human urine samples.
A concentration set including binary mixtures of levodopa and carbidopa in 15 different combinations was randomly prepared in acetate buffer (pH 3.5).).
UV spectrophotometry is a relatively inexpensive, reliable, and less time-consuming method.
Minitab program was used for absorbance and concentration values.
The normalization values for each active substance were good (r2>0.9997).
Additionally, experimental data were validated statistically.
The results of the analyses of the results revealed high recoveries and low standard deviations.
Hence, the results encouraged us to apply the method to drug analysis.
The proposed methods are highly sensitive and precise, and therefore they were implemented for the determination of the active substances in the urine sample of a healthy person in triumph.
American Psychological Association (APA)
Ertokus, Guzide Pekcan. 2019. The Determination of Parkinson’s Drugs in Human Urine by Applying Chemometric Methods. International Journal of Analytical Chemistry،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1155974
Modern Language Association (MLA)
Ertokus, Guzide Pekcan. The Determination of Parkinson’s Drugs in Human Urine by Applying Chemometric Methods. International Journal of Analytical Chemistry No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1155974
American Medical Association (AMA)
Ertokus, Guzide Pekcan. The Determination of Parkinson’s Drugs in Human Urine by Applying Chemometric Methods. International Journal of Analytical Chemistry. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1155974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155974