The Effect of Hepatosteatosis on Response to Antiviral Treatment in Patients with Chronic Hepatitis B: A Meta-Analysis
Joint Authors
Yang, Qiao
Zhu, Yongfen
Lv, Fangfang
Yu, Yunsong
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
This study is to systematically analyze the effects of hepatosteatosis on the response to antiviral treatment in patients with chronic hepatitis B (CHB) and hepatosteatosis.
Methods.
Systematic search was performed in PubMed, Embase, Web of Science, Elsevier, and the Chinese BioMedical literature databases for relevant studies published until February 2016.
Treatment outcomes were compared between patients with CHB plus concomitant hepatosteatosis and those without hepatosteatosis.
Results.
A total of 8 prospective cohort studies (399 patients with CHB plus hepatosteatosis and 688 patients with only CHB) were included.
Biochemical and virological response at both 48 and 96 weeks were significantly lower in patients with CHB plus hepatosteatosis as compared to that in patients with only CHB.
Subgroup analysis based on methods used for diagnosis of hepatosteatosis and treatment regimens showed that when hepatosteatosis was diagnosed on Doppler ultrasound and treated with nucleotide analogues, patients with CHB plus hepatosteatosis showed lower biochemical (62.7% versus 75.8%, P=0.002) and virological response (66.2% versus 72.3%, P=0.006) as compared to that in patients with CHB.
Conclusion.
Hepatosteatosis lowers the efficacy of antiviral treatment in patients with CHB, especially when hepatosteatosis was diagnosed on ultrasound findings and treated with nucleotide analogues.
American Psychological Association (APA)
Zhu, Yongfen& Yang, Qiao& Lv, Fangfang& Yu, Yunsong. 2017. The Effect of Hepatosteatosis on Response to Antiviral Treatment in Patients with Chronic Hepatitis B: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1156113
Modern Language Association (MLA)
Zhu, Yongfen…[et al.]. The Effect of Hepatosteatosis on Response to Antiviral Treatment in Patients with Chronic Hepatitis B: A Meta-Analysis. Gastroenterology Research and Practice No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1156113
American Medical Association (AMA)
Zhu, Yongfen& Yang, Qiao& Lv, Fangfang& Yu, Yunsong. The Effect of Hepatosteatosis on Response to Antiviral Treatment in Patients with Chronic Hepatitis B: A Meta-Analysis. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1156113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156113