Parallel Changes in Harvey-Bradshaw Index, TNFα, and Intestinal Fatty Acid Binding Protein in Response to Infliximab in Crohn’s Disease
Joint Authors
Hellström, Per M.
Al-Saffar, Anas Kh.
Meijer, Carl Hampus
Gannavarapu, Venkata Ram
Hall, Gustav
Li, Yichen
Diaz Tartera, Hetzel O.
Lördal, Mikael
Ljung, Tryggve
Webb, Dominic-Luc
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Intestinal fatty acid binding protein (I-FABP) indicates barrier integrity.
Aims: determine if I-FABP is elevated in active Crohn’s disease (CD) and if I-FABP parallels anti-TNFα antibody (infliximab) induced lowering of TNFα and Harvey-Bradshaw Index (HBI) as potential indicator of mucosal healing.
I-FABP distribution along human gut was determined.
Serum from 10 CD patients collected during first three consecutive infliximab treatments with matched pretreatment and follow-up samples one week after each treatment and corresponding HBI data were analyzed.
I-FABP reference interval was established from 31 healthy subjects with normal gut permeability.
I-FABP and TNFα were measured by ELISA; CRP was measured by nephelometry.
Healthy tissue was used for I-FABP immunohistochemistry.
Pretreatment CD patient TNFα was 1.6-fold higher than in-house reference interval, while I-FABP was 2.5-fold higher, which lowered at follow-ups.
Combining all 30 infusion/follow-up pairs also revealed changes in I-FABP.
HBI followed this pattern; CRP declined gradually.
I-FABP was expressed in epithelium of stomach, jejunum, ileum, and colon, with the highest expression in jejunum and ileum.
I-FABP is elevated in active CD with a magnitude comparable to TNFα.
Parallel infliximab effects on TNFα, HBI, and I-FABP were found.
I-FABP may be useful as an intestine selective prognostic marker in CD.
American Psychological Association (APA)
Al-Saffar, Anas Kh.& Meijer, Carl Hampus& Gannavarapu, Venkata Ram& Hall, Gustav& Li, Yichen& Diaz Tartera, Hetzel O.…[et al.]. 2017. Parallel Changes in Harvey-Bradshaw Index, TNFα, and Intestinal Fatty Acid Binding Protein in Response to Infliximab in Crohn’s Disease. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156182
Modern Language Association (MLA)
Al-Saffar, Anas Kh.…[et al.]. Parallel Changes in Harvey-Bradshaw Index, TNFα, and Intestinal Fatty Acid Binding Protein in Response to Infliximab in Crohn’s Disease. Gastroenterology Research and Practice No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1156182
American Medical Association (AMA)
Al-Saffar, Anas Kh.& Meijer, Carl Hampus& Gannavarapu, Venkata Ram& Hall, Gustav& Li, Yichen& Diaz Tartera, Hetzel O.…[et al.]. Parallel Changes in Harvey-Bradshaw Index, TNFα, and Intestinal Fatty Acid Binding Protein in Response to Infliximab in Crohn’s Disease. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156182