Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties
Joint Authors
Stabili, Loredana
Acquaviva, Maria Immacolata
Cavallo, Rosa Anna
Gerardi, Carmela
Narracci, Marcella
Pagliara, Patrizia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Echinoderms are a renewable resource with an economic value due to their increasing demand as food and/or source of bioactive molecules exerting antitumor, antiviral, anticoagulant, antioxidant, and antimicrobial activities.
In this framework, the present study is aimed at investigating the antibacterial, antioxidant, and hemolytic activities in the three Echinoderm species Echinaster sepositus, Arbacia lixula, and Sphaerechinus granularis.
The sea star E.
sepositus showed lysozyme-like activity (mean diameter of lysis of 13.4±0.2 mm), an antimicrobial activity against the human emerging pathogens Staphylococcus aureus, Pseudomonas aeruginosa, and Candida famata, and a strong lytic activity (100±0.05%) towards the human red blood cells.
Furthermore A.
lixula and E.
sepositus had the highest antioxidant activity (1792.75±233.7 and 1765.65±484.58 nmolTE/mL, resp.).
From toxicological assays, it was shown that E.
sepositus was not toxic towards HeLa cells and Vibrio fischeri, encouraging the exploitation of this species in the pharmaceutical field.
Therefore, our findings have implications due to the ongoing explosion of antibiotic-resistant infections because of the new opportunistic pathogens and the need to discover antibacterial agents with new modes of action.
Also the recorded antioxidant activity taking into account the need to find natural antioxidants useful for human health is intriguing.
American Psychological Association (APA)
Stabili, Loredana& Acquaviva, Maria Immacolata& Cavallo, Rosa Anna& Gerardi, Carmela& Narracci, Marcella& Pagliara, Patrizia. 2018. Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156306
Modern Language Association (MLA)
Stabili, Loredana…[et al.]. Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156306
American Medical Association (AMA)
Stabili, Loredana& Acquaviva, Maria Immacolata& Cavallo, Rosa Anna& Gerardi, Carmela& Narracci, Marcella& Pagliara, Patrizia. Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156306