Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders
Joint Authors
Mulak, Agata
Grzesiak, Magdalena
Beszłej, Jan Aleksander
Waszczuk, Ewa
Szechiński, Marcin
Szewczuk-Bogusławska, Monika
Frydecka, Dorota
Dobosz, Tadeusz
Jonkisz, Anna
Lebioda, Arleta
Małodobra, Małgorzata
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
To assess the association of six polymorphisms in serotonin-related genes with depressive or anxiety disorders in patients with irritable bowel syndrome (IBS).
Methods.
The lifetime prevalence of depressive and anxiety disorders was assessed in 95 IBS patients (85% women) using the Munich version of the Composite International Diagnostic Interview (CIDI).
IBS was diagnosed according to the Rome III criteria.
SCL6A4 HTTLPR polymorphism (rs4795541) was determined using PCR-based method.
Single-nucleotide polymorphisms in HTR1A (rs6295), HTR2A (rs6313 and rs6311), HTR2C (rs6318), and TPH1 (rs1800532) were detected by minisequencing method.
Results.
IBS patients with depressive disorders were characterized by higher frequency of 5-HTTLPR L allele in comparison to IBS patients with anxiety disorders.
The lower frequency of 1438 A allele in HTR2A was found in IBS patients with depressive disorders in comparison to IBS patients without mental disorders.
The lower G allele frequency in HTR2C rs6318 polymorphism among IBS patients with anxiety disorders was also observed.
Conclusions.
Our results provide further evidence for the involvement of SLC6A4 rs4795541 and HTR2A rs6311 polymorphisms in the pathophysiology of depressive disorders in IBS patients.
The new findings indicate that HTR2C rs6318 polymorphism may be associated with the susceptibility to anxiety disorders in IBS patients.
American Psychological Association (APA)
Grzesiak, Magdalena& Beszłej, Jan Aleksander& Waszczuk, Ewa& Szechiński, Marcin& Szewczuk-Bogusławska, Monika& Frydecka, Dorota…[et al.]. 2017. Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156378
Modern Language Association (MLA)
Grzesiak, Magdalena…[et al.]. Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders. Gastroenterology Research and Practice No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1156378
American Medical Association (AMA)
Grzesiak, Magdalena& Beszłej, Jan Aleksander& Waszczuk, Ewa& Szechiński, Marcin& Szewczuk-Bogusławska, Monika& Frydecka, Dorota…[et al.]. Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156378