Effect of Neoadjuvant Chemoradiotherapy on Locally Advanced Rectal Mucinous Adenocarcinoma: A Propensity Score-Matched Study
Joint Authors
Sun, Yanwu
Chi, Pan
Lin, Hui-ming
Lu, Xing-rong
Huang, Ying
Xu, Zong-bin
Huang, Sheng-hui
Wang, Xiao-jie
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
To compare the surgical and oncological outcomes of rectal mucinous adenocarcinomas treated with neoadjuvant chemoradiotherapy versus surgery alone.
Methods.
A total of 167 locally advanced rectal mucinous adenocarcinoma patients treated with neoadjuvant chemoradiotherapy and surgery alone between 2008 and 2014 were matched using propensity score; the surgical and oncological outcomes were compared.
Results.
Ninety-six patients were matched.
Postoperative morbidity was similar between groups.
Sphincter preservation rate was higher in patients receiving neoadjuvant chemoradiotherapy (79.2% versus 60.4%, P=0.045), especially for tumors ≥ 3 cm but ≤5 cm from the anal verge (75.0% versus 44.0%, P=0.036).
With a median follow-up of 54.8 months, the 5-year overall survival rate (neoadjuvant chemoradiotherapy versus surgery alone: 79.6% versus 67.1%; P=0.599) and disease-free survival rate (75.6% versus 64.2%; P=0.888) were similar.
The 5-year local recurrence rate was lower in patients receiving neoadjuvant chemoradiotherapy (7.7% versus 26.0%, P=0.036), while no difference was observed in distant metastasis.
A poor response to chemoradiation was associated with higher local recurrence (P=0.037).
Conclusions.
Compared with surgery alone, neoadjuvant chemoradiotherapy was found to increase the sphincter preservation rate and reduce local recurrence, thus being beneficial for locally advanced rectal mucinous adenocarcinoma patients.
American Psychological Association (APA)
Sun, Yanwu& Chi, Pan& Lin, Hui-ming& Lu, Xing-rong& Huang, Ying& Xu, Zong-bin…[et al.]. 2017. Effect of Neoadjuvant Chemoradiotherapy on Locally Advanced Rectal Mucinous Adenocarcinoma: A Propensity Score-Matched Study. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1156477
Modern Language Association (MLA)
Sun, Yanwu…[et al.]. Effect of Neoadjuvant Chemoradiotherapy on Locally Advanced Rectal Mucinous Adenocarcinoma: A Propensity Score-Matched Study. Gastroenterology Research and Practice No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1156477
American Medical Association (AMA)
Sun, Yanwu& Chi, Pan& Lin, Hui-ming& Lu, Xing-rong& Huang, Ying& Xu, Zong-bin…[et al.]. Effect of Neoadjuvant Chemoradiotherapy on Locally Advanced Rectal Mucinous Adenocarcinoma: A Propensity Score-Matched Study. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1156477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156477