Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer
Joint Authors
Sun, Der Sheng
Hong, Soon Auck
Yoo, Su Hyun
Lee, Han Hong
Kim, Okran
Won, Hye Sung
Ko, Yoon Ho
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Caveolin-1 (Cav-1), as the main component of caveolae, has complex roles in tumourigenesis in human malignancies.
We investigated Cav-1 in primary and metastatic tumor cells of gastric cancer (GC) and its association with clinical outcomes.
Methods.
We retrieved 145 cases of GC who had undergone curative gastrectomy.
The expression levels of Cav-1 was evaluated by immunohistochemistry, and its association with clinicopathological parameters and patient survival was analyzed.
Results.
High expression of Cav-1 protein of the GC in the stomach and metastatic lymph node was 12.4% (18/145) and 16.5% (15/91).
In the multivariate analysis, tumoral Cav-1 protein in metastatic lymph node showed prognostic significance for relapse-free survival (RFS, HR, 3.934; 95% CI, 1.882–8.224; P=0.001) and cancer-specific survival outcome (CSS, HR, 2.681; 95% CI, 1.613–8.623; P=0.002).
Among the GCs with metastatic lymph node, it remained as a strong indicator of poor prognosis for RFS (HR, 3.136; 95% CI, 1.444–6.810; P=0.004) and CSS (HR, 2.509; 95% CI, 1.078–5.837; P=0.032).
Conclusion.
High expression of tumoral Cav-1 protein in metastatic lymph node is associated with unfavorable prognosis of curative resected GC, indicating the potential of novel prognostic markers.
American Psychological Association (APA)
Sun, Der Sheng& Hong, Soon Auck& Won, Hye Sung& Yoo, Su Hyun& Lee, Han Hong& Kim, Okran…[et al.]. 2017. Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1156496
Modern Language Association (MLA)
Sun, Der Sheng…[et al.]. Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer. Gastroenterology Research and Practice No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1156496
American Medical Association (AMA)
Sun, Der Sheng& Hong, Soon Auck& Won, Hye Sung& Yoo, Su Hyun& Lee, Han Hong& Kim, Okran…[et al.]. Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1156496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156496