Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study
Joint Authors
Märkl, B.
Schaller, Tina
Hardt, Jochen
Franz, Simon
Schenkirsch, Gerhard
Kriening, Bernadette
Hoffmann, Reinhard
Rüth, Stefan
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
The prognostic role of the proteases uPA and PAI-1, as well as tumor budding, in colon cancer, has been investigated previously.
Methods.
We provide 6-year follow-up data and results of the validation set.
The initial test set and validation set consisted of 55 colon cancers and 68 colorectal cancers, respectively.
Tissue samples were analyzed for uPA and PAI-1 using a commercially available Enzyme-Linked Immunosorbent Assay (ELISA).
Tumor budding was analyzed on cytokeratin-stained slides.
Survival analyses were performed using cut-offs that were determined previously.
Results.
uPA was not prognostic for outcome.
PAI-1 showed a trend towards reduced cancer specific survival in PAI-1 high-grade cases (68 versus 83 months; P=0.091).
The combination of high-grade PAI-1 and tumor budding was associated with significantly reduced cancer specific survival (60 versus 83 months; P=0.021).
After pooling the data from both sets, multivariate analyses revealed that the factors pN-stage, V-stage, and a combination of tumor budding and PAI-1 were independently prognostic for the association with distant metastases.
Conclusions.
A synergistic adverse effect of PAI-1 and tumor budding in uni- and multivariable analyses was found.
PAI-1 could serve as a target for anticancer therapy.
American Psychological Association (APA)
Märkl, B.& Hardt, Jochen& Franz, Simon& Schaller, Tina& Schenkirsch, Gerhard& Kriening, Bernadette…[et al.]. 2017. Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1156539
Modern Language Association (MLA)
Märkl, B.…[et al.]. Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study. Gastroenterology Research and Practice No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1156539
American Medical Association (AMA)
Märkl, B.& Hardt, Jochen& Franz, Simon& Schaller, Tina& Schenkirsch, Gerhard& Kriening, Bernadette…[et al.]. Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1156539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156539