Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East
Joint Authors
Liu, Muyun
Xia, Tian
Zhang, Di
Hu, Lianghao
Liao, Zhuan
Sun, Chang
Li, Zhaoshen
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The clinical pattern and genetic background of juvenile idiopathic chronic pancreatitis (ICP) are yet unclear.
Methods.
A retrospective study of 73 Chinese juvenile ICP patients was performed, and genetic tests were carried out to detect relevant mutations using direct sequencing technique and high-resolution melting technique.
Subjects without pancreatitis served as controls.
Results.
The SPINK1 c.194+2T>C variant was present in 56.16% and 42.00% of juvenile and adult ICP patients, respectively (p=0.020), but was not present in any of the control subjects.
Thirty-four (46.58%) of the 73 juvenile ICP patients were male, and a significantly higher ratio of male patients in the adult group was identified (46.58% versus 64.00%, p=0.022).
Although most of the juvenile patients presented with abdominal pain (70/73, 95.89%), the patterns of pain attack are significantly different in patients with or without SPINK1 c.194+2T>C mutation.
Patients carrying the mutation are more likely to present with recurrent acute pancreatitis (70.70%).
Conclusions.
The main symptom of pediatric ICP was abdominal pain.
SPINK1 c.194+2T>C mutation had a higher occurrence in juvenile ICP patients than in adult group and typically presented with recurrent acute pancreatitis.
There may be unidentified factors that lead to a greater incidence rate of ICP in adult male population.
American Psychological Association (APA)
Liu, Muyun& Xia, Tian& Zhang, Di& Hu, Lianghao& Liao, Zhuan& Sun, Chang…[et al.]. 2017. Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156607
Modern Language Association (MLA)
Liu, Muyun…[et al.]. Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East. Gastroenterology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1156607
American Medical Association (AMA)
Liu, Muyun& Xia, Tian& Zhang, Di& Hu, Lianghao& Liao, Zhuan& Sun, Chang…[et al.]. Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156607