Inhibition of α-Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea
Joint Authors
Aziz, Mohammed
Bouhrim, Mohamed
Bnouham, Mohamed
Legssyer, A.
Ziyyat, A.
Mekhfi, H.
Ouassou, Hayat
Zahidi, Touda
Bouknana, Saliha
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Many medicinal plants around the world are used for therapeutic purposes against several diseases, including diabetes mellitus.
Due to their composition of natural substances that are effective and do not represent side effects for users, unlike synthetic drugs, in this study, we investigated the inhibitory effect of Caralluma europaea (CE) on α-glucosidase activity in vitro; then the kinetics of the enzyme were studied with increasing concentrations of sucrose in order to determine the inhibition type of the enzyme.
In addition, this effect of Caralluma europaea (CE) was confirmed in vivo using rats as an experimental animal model.
Among the five fractions of CE, only the ethyl acetate fraction of C.
europaea (EACe) induced a significant inhibition of α-glucosidase and its inhibition mode was competitive.
The in vivo studies were conducted on mice and rats using glucose and sucrose as a substrate, respectively, to determine the oral glucose tolerance test (OGTT).
The results obtained showed that the EACe and the aqueous extract of C.
europaea (AECe) have significantly reduced the postprandial hyperglycemia after sucrose and glucose loading in normal and diabetic rats.
AECe, also, significantly decreased intestinal glucose absorption, in situ.
The results obtained showed that Caralluma europaea has a significant antihyperglycemic activity, which could be due to the inhibition of α-glucosidase activity and enteric absorption of glucose.
American Psychological Association (APA)
Ouassou, Hayat& Zahidi, Touda& Bouknana, Saliha& Bouhrim, Mohamed& Mekhfi, H.& Ziyyat, A.…[et al.]. 2018. Inhibition of α-Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156925
Modern Language Association (MLA)
Ouassou, Hayat…[et al.]. Inhibition of α-Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156925
American Medical Association (AMA)
Ouassou, Hayat& Zahidi, Touda& Bouknana, Saliha& Bouhrim, Mohamed& Mekhfi, H.& Ziyyat, A.…[et al.]. Inhibition of α-Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156925