An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak-Gamcho Decoction: A Network Pharmacology Study

Joint Authors

Lee, In-Hee
Kang, Kyungrae
Kwon, Tae-Wook
Lee, Dae-Yeon
Lee, Ho-Sung
Park, Sang-In

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-20, 20 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-04

Country of Publication

Egypt

No. of Pages

20

Main Subjects

Medicine

Abstract EN

Herbal drugs have drawn substantial interest as effective analgesic agents; however, their therapeutic mechanisms remain to be fully understood.

To address this question, we performed a network pharmacology study to explore the system-level mechanisms that underlie the analgesic activity of Jakyak-Gamcho decoction (JGd; Shaoyao-Gancao-Tang in Chinese and Shakuyaku-Kanzo-To in Japanese), an herbal prescription consisting of Paeonia lactiflora Pallas and Glycyrrhiza uralensis Fischer.

Based on comprehensive information regarding the pharmacological and chemical properties of the herbal constituents of JGd, we identified 57 active chemical compounds and their 70 pain-associated targets.

The JGd targets were determined to be involved in the regulation of diverse biological activities as follows: calcium- and cytokine-mediated signalings, calcium ion concentration and homeostasis, cellular behaviors of muscle and neuronal cells, inflammatory response, and response to chemical, cytokine, drug, and oxidative stress.

The targets were further enriched in various pain-associated signalings, including the PI3K-Akt, estrogen, ErbB, neurotrophin, neuroactive ligand-receptor interaction, HIF-1, serotonergic synapse, JAK-STAT, and cAMP pathways.

Thus, these data provide a systematic basis to understand the molecular mechanisms underlying the analgesic activity of herbal drugs.

American Psychological Association (APA)

Lee, Ho-Sung& Lee, In-Hee& Kang, Kyungrae& Park, Sang-In& Kwon, Tae-Wook& Lee, Dae-Yeon. 2020. An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak-Gamcho Decoction: A Network Pharmacology Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1157009

Modern Language Association (MLA)

Lee, Ho-Sung…[et al.]. An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak-Gamcho Decoction: A Network Pharmacology Study. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1157009

American Medical Association (AMA)

Lee, Ho-Sung& Lee, In-Hee& Kang, Kyungrae& Park, Sang-In& Kwon, Tae-Wook& Lee, Dae-Yeon. An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak-Gamcho Decoction: A Network Pharmacology Study. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1157009

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1157009