β-Asarone Increases Chemosensitivity by Inhibiting Tumor Glycolysis in Gastric Cancer
Joint Authors
Zou, Xi
Wu, Jian
Ding, Xue-Lian
Tao, Heyun
Liu, Shenlin
Sun, Wei
Nie, Mengjun
Pan, Xiaoting
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
β-asarone is the main active ingredient of the Chinese herb Rhizoma Acori Tatarinowii, which exhibits a wide range of biological activities.
It was confirmed to be an efficient cytotoxic agent against gastroenteric cancer cells.
However, the exact mechanism of β-asarone in gastric cancer (GC) remains to be elucidated.
The present study showed the inhibitory effect of β-asarone on three types of different differentiation stage GC cell lines (MGC803, SGC7901, and MKN74) in a dose-dependent manner.
Meanwhile, the synergistic sensitivity of β-asarone and cisplatin was confirmed by using the median-effect principle.
Flow cytometry assay revealed that under both normoxia and CoCl2-induced hypoxia conditions, β-asarone can induce apoptosis of GC cells, which can block GC cells in the cell cycle G2/M phase, showing obvious subdiploid peak.
Moreover, the activity of lactic dehydrogenase (LDH), an enzyme that plays an important role in the final step of tumor glycolysis, was significantly decreased in GC cells following treatment with β-asarone.
Mechanistically, β-asarone can reduce pyruvate dehydrogenase kinase (PDK) 1, phospho(p)-PDK1, PDK4, hypoxia-inducible factor 1-α (HIF1α), c-myc, STAT5, and p-STAT5 expression, which revealed how β-asarone affects tumor glycolysis.
In conclusion, the present study provided evidence in support of the hypothesis that the increase of chemotherapy sensitization by β-asarone is associated with the inhibition of tumor glycolysis.
American Psychological Association (APA)
Tao, Heyun& Ding, Xue-Lian& Wu, Jian& Liu, Shenlin& Sun, Wei& Nie, Mengjun…[et al.]. 2020. β-Asarone Increases Chemosensitivity by Inhibiting Tumor Glycolysis in Gastric Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1157144
Modern Language Association (MLA)
Tao, Heyun…[et al.]. β-Asarone Increases Chemosensitivity by Inhibiting Tumor Glycolysis in Gastric Cancer. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1157144
American Medical Association (AMA)
Tao, Heyun& Ding, Xue-Lian& Wu, Jian& Liu, Shenlin& Sun, Wei& Nie, Mengjun…[et al.]. β-Asarone Increases Chemosensitivity by Inhibiting Tumor Glycolysis in Gastric Cancer. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1157144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157144