Association between the APOE ε4 Allele and Late-Onset Alzheimer’s Disease in an Ecuadorian Mestizo Population
Joint Authors
Montufar, Stefany
Calero, Cristian
Vinueza, Rodrigo
Correa, Patricio
Carrera-Gonzalez, Andrea
Villegas, Franklin
Moreta, Germania
Paredes, Rosario
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common neurodegenerative disease.
It has two main pathological hallmarks: amyloid plaques and neurofibrillary tangles.
The APOE ε4 allele has been recognized as the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD) in several populations worldwide, yet the risk varies by region and ethnicity.
The aims of this study were to describe APOE allele and genotype frequencies and examine the relationship between the APOE ε4 allele and LOAD risk in an Ecuadorian Mestizo population.
We carried out a case-control study comprising 56 individuals clinically diagnosed with probable AD (≥65 years of age) and 58 unrelated healthy control subjects (≥65 years of age).
Genotyping was performed using the real-time PCR method.
Our data showed that allelic and genotypic frequencies follow the trends observed in most worldwide populations.
We also found a high-risk association between APOE ε4 allele carriers and LOAD (OR = 7.286; 95% CI = 2.824–18.799; p<0.001).
Therefore, we concluded that APOE ε4 must be considered an important genetic risk factor for LOAD in the Ecuadorian Mestizo population.
Additionally, we suggest that in mixed populations the effects of admixture and ethnic identity should be differentiated when evaluating genetic contributions to Alzheimer’s disease risk.
American Psychological Association (APA)
Montufar, Stefany& Calero, Cristian& Vinueza, Rodrigo& Correa, Patricio& Carrera-Gonzalez, Andrea& Villegas, Franklin…[et al.]. 2017. Association between the APOE ε4 Allele and Late-Onset Alzheimer’s Disease in an Ecuadorian Mestizo Population. International Journal of Alzheimer's Disease،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1157669
Modern Language Association (MLA)
Montufar, Stefany…[et al.]. Association between the APOE ε4 Allele and Late-Onset Alzheimer’s Disease in an Ecuadorian Mestizo Population. International Journal of Alzheimer's Disease No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1157669
American Medical Association (AMA)
Montufar, Stefany& Calero, Cristian& Vinueza, Rodrigo& Correa, Patricio& Carrera-Gonzalez, Andrea& Villegas, Franklin…[et al.]. Association between the APOE ε4 Allele and Late-Onset Alzheimer’s Disease in an Ecuadorian Mestizo Population. International Journal of Alzheimer's Disease. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1157669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157669