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Serum TLR9 and NF-κB Biochemical Markers in Patients with Acute Pancreatitis on Admission
Joint Authors
Aydın, Hüseyin
Szarpak, Lukasz
Demirtas, Erdal
Korkmaz, İlhan
Cebecioğlu, Kıvanç
Ayan, Mustafa
Demirtaş, Esin
Yurtbay, Sefa
Yıldız, Şeymanur
Source
Emergency Medicine International
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
The aim of this study was to investigate the serum TLR9 and NF-κB levels in patients for the diagnosis and prognostication of AP in the emergency department.
Methods.
In the current study, we looked at the TLR9 and NF-κB pathways in a cohort of 45 acute pancreatitis patients and compared them with the control group.
We also divided the patient groups as mild-moderate or severe and compared the biomarker levels between the groups.
Results.
Of the patients with acute pancreatitis, 22 (49%) were male and 23 (51%) were female.
The mean age of the patient group was 62 years, with a range of 25–95 years.
The control group consisted of 19 (43.1%) male and 25 (56.9%) female patients.
The serum TLR9 and NF-κB values were significantly higher than those of the control group [1104.44 ± 339.20 vs.
702.08 ± 203.94; p<0.001 and 8.04 ± 1.76 vs.
4.76 ± 1.13; p<0.001, respectively].
We found that TLR9 and NF-κB had a significant discriminative ability, while the cutoff value for TLR9 was 950.4, with a sensitivity of 73% and specificity of 93% (p<0.001), and the cutoff value for NF-κB was 6.32, with a sensitivity of 89% and specificity of 100% (p<0.001).
Conclusion.
We demonstrated that the TLR9 and NF-κB pathway is activated in acute pancreatitis and increases the inflammatory process.
This may help to further understand the pathogenesis of disorder, diagnosis, and clinical severity.
We proposed that blockage of these inflammatory pathways may play a role in the prevention of the disease progression and development of inflammatory complications.
American Psychological Association (APA)
Demirtas, Erdal& Korkmaz, İlhan& Cebecioğlu, Kıvanç& Ayan, Mustafa& Demirtaş, Esin& Yurtbay, Sefa…[et al.]. 2020. Serum TLR9 and NF-κB Biochemical Markers in Patients with Acute Pancreatitis on Admission. Emergency Medicine International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1158993
Modern Language Association (MLA)
Demirtas, Erdal…[et al.]. Serum TLR9 and NF-κB Biochemical Markers in Patients with Acute Pancreatitis on Admission. Emergency Medicine International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1158993
American Medical Association (AMA)
Demirtas, Erdal& Korkmaz, İlhan& Cebecioğlu, Kıvanç& Ayan, Mustafa& Demirtaş, Esin& Yurtbay, Sefa…[et al.]. Serum TLR9 and NF-κB Biochemical Markers in Patients with Acute Pancreatitis on Admission. Emergency Medicine International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1158993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158993