Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age
Joint Authors
Chao, David T.
Shah, Nilesh H.
Zeh, Herbert J.
Singhi, Aatur D.
Bahary, Nathan
McGrath, Kevin M.
Fasanella, Kenneth E.
Zureikat, Amer H.
Whitcomb, David C.
Brand, Randall E.
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Adolescent obesity is a national epidemic that recently has been shown to increase risk for pancreatic adenocarcinoma (PC) and is associated with an earlier age of PC onset.
We hypothesized that PC patients who are overweight or obese at age 18 would have an earlier age of PC onset.
Methods.
Retrospective review of 531 patients in our PC registry was completed.
Self-reported weight at age 18 and maximum lifetime weight were used to calculate body mass index (BMI) at age 18 (BMI-18) and maximum lifetime BMI.
Results.
Complete BMI and baseline covariate data was available in 319 PC patients.
Mean age (in years) of PC diagnosis for patients whose BMI-18 was overweight (64.0) or obese (59.9) was significantly different when compared to patients with a normal BMI-18 (66.7).
No significant difference was observed in the mean age of PC diagnosis in those patients who maintained a normal BMI-18 when compared to those patients who subsequently became overweight or obese (67.0 versus 66.6; p=0.65).
Conclusions.
An elevated BMI at age 18 is associated with an earlier age of PC onset and should be factored into determining the optimal age of beginning screening for patients at high risk for PC.
American Psychological Association (APA)
Chao, David T.& Shah, Nilesh H.& Zeh, Herbert J.& Singhi, Aatur D.& Bahary, Nathan& McGrath, Kevin M.…[et al.]. 2018. Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1159381
Modern Language Association (MLA)
Chao, David T.…[et al.]. Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age. Gastroenterology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1159381
American Medical Association (AMA)
Chao, David T.& Shah, Nilesh H.& Zeh, Herbert J.& Singhi, Aatur D.& Bahary, Nathan& McGrath, Kevin M.…[et al.]. Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1159381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159381