Risk Factors Associated with the Occurrence of Autoimmune Diseases in Adult Coeliac Patients
Joint Authors
Annibale, Bruno
Conti, Laura
Lahner, Edith
Galli, Gloria
Esposito, Gianluca
Carabotti, Marilia
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Autoimmune diseases (AD) may be associated with coeliac disease (CD), but specific risk factors have been poorly investigated.
The aim of this study was to assess the spectrum of AD and its specific risk factors associated in a series of adult coeliac patients.
Materials and Methods.
We performed a single-center case-control study including adult newly diagnosed CD patients.
To evaluate the risk factors of the association between AD and CD, 341 coeliac patients included were categorized on the basis of AD presence: 91 cases with at least one AD and 250 controls without AD were compared for clinical, serological, and histological features.
Eighty-seven cases were age-gender-matched with 87 controls.
Results.
Among 341 CD patients, 26.6% of CD patients had at least one AD.
Endocrine and dermatological diseases were the most prevalent AD encountered: autoimmune thyroiditis was present in 48.4% of cases, psoriasis in 17.6%, and type I diabetes and dermatitis herpetiformis in 11%, respectively.
At logistic regression, factors associated with AD were a positive 1st-degree family history of AD (OR 3.7, 95% CI 1.93–7), a body mass index ≥ 25 kg/m2 at CD diagnosis (OR 2.95%, CI 1.1–3.8), and long standing presentation signs/symptoms before CD diagnosis (>10 years) (OR 2.1, 95% CI 1.1–3.7).
Analysis on age-gender-matched patients confirmed these results.
Conclusions.
CD patients with family history of AD, overweight at CD diagnosis, and a delay of CD diagnosis had an increased risk of having another AD.
The benefit of CD screening in these specific subsets of patients with AD awaits further investigation.
American Psychological Association (APA)
Conti, Laura& Lahner, Edith& Galli, Gloria& Esposito, Gianluca& Carabotti, Marilia& Annibale, Bruno. 2018. Risk Factors Associated with the Occurrence of Autoimmune Diseases in Adult Coeliac Patients. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1159485
Modern Language Association (MLA)
Conti, Laura…[et al.]. Risk Factors Associated with the Occurrence of Autoimmune Diseases in Adult Coeliac Patients. Gastroenterology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1159485
American Medical Association (AMA)
Conti, Laura& Lahner, Edith& Galli, Gloria& Esposito, Gianluca& Carabotti, Marilia& Annibale, Bruno. Risk Factors Associated with the Occurrence of Autoimmune Diseases in Adult Coeliac Patients. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1159485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159485