Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies
Joint Authors
Paprocka, Justyna
Sokół, Maria
Kijonka, Marek
Rzepka, Beata
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Melatonin may serve as a potential therapeutic free radical scavenger and broad-spectrum antioxidant.
It shows neuroprotective properties against hypoxic-ischemic brain injury in animal models.
The authors review the studies focusing on the neuroprotective potential of melatonin and its possibility of treatment after perinatal asphyxia.
Melatonin efficacy, low toxicity, and ability to readily cross through the blood-brain barrier make it a promising molecule.
A very interesting thing is the difference between the half-life of melatonin in preterm neonates (15 hours) and adults (45-60 minutes).
Probably, the use of synergic strategies—hypothermia coupled with melatonin treatment—may be promising in improving antioxidant action.
The authors discuss and try to summarize the evidence surrounding the use of melatonin in hypoxic-ischemic events in term and preterm babies.
American Psychological Association (APA)
Paprocka, Justyna& Kijonka, Marek& Rzepka, Beata& Sokół, Maria. 2019. Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1165128
Modern Language Association (MLA)
Paprocka, Justyna…[et al.]. Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies. International Journal of Endocrinology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1165128
American Medical Association (AMA)
Paprocka, Justyna& Kijonka, Marek& Rzepka, Beata& Sokół, Maria. Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1165128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165128