Safety of Propofol versus Nonpropofol-Based Sedation in Children Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis
Joint Authors
Narula, Neeraj
Masood, Sameer
Shojaee, Samira
McGuinness, Brandon
Sabeti, Saama
Buchan, Arianne
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The majority of children who undergo gastrointestinal (GI) endoscopy require anesthesia or procedural sedation for comfort, cooperation, and procedure efficiency.
The safety profile of propofol is not well established in children but has been studied in the literature.
Objective.
The aim of this study is to evaluate and compare the safety of propofol-only sedation for GI endoscopy procedures to other anesthetic regimes in the pediatric population.
Methods.
A search was conducted in the MEDLINE, Embase, and Cochrane Library databases.
Randomized clinical trials and prospective cohorts were included in the study.
Results.
No significant difference was noted in total complications between the two cohorts with a pooled OR of 1.31 (95% CI: 0.57–3.04, chi2 = 0.053, I2 = 54.31%).
The pooled rate of complications in the studies was 23.4% for those receiving propofol only and 18.2% for those receiving other anesthetic regimens.
Sensitivity analysis was performed removing a study with a very different control comparison compared to the rest of the studies included.
Once excluded, there was minimal heterogeneity in the remaining studies and a significant difference in overall complications was detected, with more complications seen in the propofol-only group compared to the other anesthetic groups (OR 1.87, 95% CI 1.09–3.20).
Conclusion.
Significantly higher incidence of cardiorespiratory complications was noted in the propofol-only versus other anesthetic regimens in pediatric patients undergoing GI endoscopy in this meta-analysis.
However, the overall quality of the evidence is very low.
How to Apply This Knowledge for Routine Clinical Practice.
Clinicians providing sedation to a pediatric population for GI endoscopy should consider there may be increased risks when using a propofol-only regimen, but further study is needed.
American Psychological Association (APA)
Narula, Neeraj& Masood, Sameer& Shojaee, Samira& McGuinness, Brandon& Sabeti, Saama& Buchan, Arianne. 2018. Safety of Propofol versus Nonpropofol-Based Sedation in Children Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1165309
Modern Language Association (MLA)
Narula, Neeraj…[et al.]. Safety of Propofol versus Nonpropofol-Based Sedation in Children Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1165309
American Medical Association (AMA)
Narula, Neeraj& Masood, Sameer& Shojaee, Samira& McGuinness, Brandon& Sabeti, Saama& Buchan, Arianne. Safety of Propofol versus Nonpropofol-Based Sedation in Children Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1165309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165309