Statin Use and Cancer Incidence in Patients with Type 2 Diabetes Mellitus: A Network Meta-Analysis
Joint Authors
Hu, Yi-Bing
Hu, En-De
Fu, Rong-Quan
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Type 2 diabetes mellitus (T2DM) patients are involved closely with cancer.
This work aims to conduct a systematic review and network meta-analysis (NMA) to examine the effect of different types of statins on cancer incidence in patients with T2DM.
Methods.
We systematically searched the Cochrane Library, PubMed, Embase, and Wanfang databases from January 1999 to March 2017.
We performed a pairwise meta-analysis to estimate the pooled ratios (ORs) and 95% confidence intervals (CIs).
A NMA was performed to compare different types of statins.
Results.
Seven publications were included.
In pairwise meta-analysis, the incidence of cancer in T2DM patients was reduced when simvastatin, atorvastatin, pravastatin, fluvastatin, lovastatin, rosuvastatin, and pitavastatin were used.
In the result of NMA, the usage of simvastatin (RR 0.30 and 95% CI 0.16–0.56), atorvastatin (RR 0.29 and 95% CI 0.09–0.88), pravastatin (RR 0.34 and 95% CI 0.12–0.93), fluvastatin (RR 0.27 and 95% CI 0.09–0.83), rosuvastatin (RR 0.22 and 95% CI 0.10–0.49), and pitavastatin (RR 0.33 and 95% CI 0.20–0.57) was superior to the nonstatin groups.
When compared with six other statins, rosuvastatin appeared to be the best one.
Conclusions.
Different statins can reduce the risk of cancer in patients with T2DM.
Our analyses suggest that rosuvastatin may be more effective than others.
American Psychological Association (APA)
Hu, Yi-Bing& Hu, En-De& Fu, Rong-Quan. 2018. Statin Use and Cancer Incidence in Patients with Type 2 Diabetes Mellitus: A Network Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165752
Modern Language Association (MLA)
Hu, Yi-Bing…[et al.]. Statin Use and Cancer Incidence in Patients with Type 2 Diabetes Mellitus: A Network Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1165752
American Medical Association (AMA)
Hu, Yi-Bing& Hu, En-De& Fu, Rong-Quan. Statin Use and Cancer Incidence in Patients with Type 2 Diabetes Mellitus: A Network Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165752