Associations of Salivary BPIFA1 Protein in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus
Joint Authors
Guo, Yue
Guo, Lin-Na
Zhu, Jun-Fei
Tang, Chen-Yi
Feng, Yun-Zhi
Zhou, Hou-De
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aims.
To explore the differences in salivary BPI fold containing family A, member 1 (BPIFA1) concentration among type 2 diabetes mellitus (T2DM) subjects with various severities of chronic periodontitis and to determine whether BPIFA1 in saliva can be used as a potential biomarker of T2DM.
Methods.
Unstimulated saliva samples were collected from 44 subjects with T2DM and 44 without T2DM (NDM).
Additionally, demographic data and general health parameters, including fasting blood glucose (FBG) and body mass index (BMI), were collected.
We also detected full-mouth clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), bleeding index (BI), and plaque index (PLI).
Salivary BPIFA1, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) concentrations were also detected.
Results.
BPIFA1 in saliva was detected at relatively high levels.
T2DM subjects had decreased salivary BPIFA1 concentrations (P=0.031).
In T2DM subjects with nonperiodontitis or severe periodontitis, the level of BPIFA1 was significantly lower compared with that of NDM.
Salivary TNF-α concentration displayed a similar trend to BPIFA1 in the NDM group.
Conclusions.
BPIFA1 protein is rich in saliva and might be used as a potential predictive biomarker of T2DM, especially in patients with severe periodontitis and nonperiodontitis.
This trial is registered with ChiCTR-ROC-17010310.
American Psychological Association (APA)
Guo, Yue& Guo, Lin-Na& Zhu, Jun-Fei& Tang, Chen-Yi& Feng, Yun-Zhi& Zhou, Hou-De. 2017. Associations of Salivary BPIFA1 Protein in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1165973
Modern Language Association (MLA)
Guo, Yue…[et al.]. Associations of Salivary BPIFA1 Protein in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1165973
American Medical Association (AMA)
Guo, Yue& Guo, Lin-Na& Zhu, Jun-Fei& Tang, Chen-Yi& Feng, Yun-Zhi& Zhou, Hou-De. Associations of Salivary BPIFA1 Protein in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1165973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165973