Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes
Joint Authors
Duan, Peng
Yang, Min
Wei, Meilin
Liu, Jia
Tu, Ping
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance.
A total of 271 unrelated Chinese postmenopausal women were recruited in this study.
The subjects were divided into type 2 diabetes mellitus (T2DM) group (n=93), impaired glucose regulation (IGR) (n=90), and normal glucose regulation group (NGR) (n=88), according to different glucose regulation categories.
Serum OPG levels were measured by enzyme-linked immunosorbent assay.
The serum OPG concentration in NGR group, 151.00 ± 45.72 pg/mL, was significantly lower than that in IGR group (169.28 ± 64.91 pg/mL) (p=0.031) and T2DM group (183.20 ± 56.53 pg/mL) (p<0.01), respectively.
In multiple linear regression analysis, HOMA-IR, age, 2hPG, AST, ALP, and eGFR were found to be independent predictors of OPG.
Increased serum OPG levels (OR = 1.009, p=0.006) may be a risk factor for insulin resistance.
The present study suggests that OPG might be implicated in the pathogenesis of diabetes and is a potential biomarker of insulin resistance in subjects with diabetes and prediabetes.
American Psychological Association (APA)
Duan, Peng& Yang, Min& Wei, Meilin& Liu, Jia& Tu, Ping. 2017. Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166682
Modern Language Association (MLA)
Duan, Peng…[et al.]. Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166682
American Medical Association (AMA)
Duan, Peng& Yang, Min& Wei, Meilin& Liu, Jia& Tu, Ping. Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166682