Simultaneous Quantification of γ-Hydroxybutyrate, γ-Butyrolactone, and 1,4-Butanediol in Four Kinds of Beverages

Joint Authors

Cao, Jin
Jin, Shaoming
Ning, Xiao
Wang, Yaonan

Source

International Journal of Analytical Chemistry

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-07-15

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Chemistry
Science

Abstract EN

γ-Hydroxybutyrate (GHB) is a neurotransmitter, which exhibits a strong central nervous system depressant effect.

The abuse of GHB or its precursor substances (γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD)) may cause serious problems.

This study developed a fast and effective UHPLC-MS/MS method for the simultaneous quantification of GHB, GBL, and 1,4-BD in four popular beverages, including carbonated drinks, tea, apple cider vinegar, and coffee.

The established method overcomes the influence of the in-source collision-induced dissociation of unstable compounds during quantification.

The limits of detection were 0.2 μg/mL for GBL and 0.5 μg/mL for GHB and 1,4-BD with excellent linearity in the range of 0.2–50 μg/mL.

The recoveries of the three compounds at three spiked levels (2.5, 5.0, and 10.0 μg/mL) in the four kinds of beverages studied were between 90 and 110%, while the relative standard deviations (RSDs) were all <10%.

The matrix effect was negligible using this simple and appropriate preprocessed procedure.

The method established in this study can quickly and reliably detect the GHB content and its analogues in beverages.

American Psychological Association (APA)

Jin, Shaoming& Ning, Xiao& Cao, Jin& Wang, Yaonan. 2020. Simultaneous Quantification of γ-Hydroxybutyrate, γ-Butyrolactone, and 1,4-Butanediol in Four Kinds of Beverages. International Journal of Analytical Chemistry،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167752

Modern Language Association (MLA)

Cao, Jin…[et al.]. Simultaneous Quantification of γ-Hydroxybutyrate, γ-Butyrolactone, and 1,4-Butanediol in Four Kinds of Beverages. International Journal of Analytical Chemistry No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1167752

American Medical Association (AMA)

Jin, Shaoming& Ning, Xiao& Cao, Jin& Wang, Yaonan. Simultaneous Quantification of γ-Hydroxybutyrate, γ-Butyrolactone, and 1,4-Butanediol in Four Kinds of Beverages. International Journal of Analytical Chemistry. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167752

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1167752