Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease
Joint Authors
Kawamura, Yoichi
Takeshita, Seiichiro
Kanai, Takashi
Takizawa, Mari
Yoshida, Yusuke
Tsujita, Yuki
Nonoyama, Shigeaki
Source
International Journal of Pediatrics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Abnormal urinary findings, such as sterile pyuria, proteinuria, and microscopic hematuria, are often seen in the acute phase of Kawasaki disease (KD).
We investigated the potential significance of urinary lactate dehydrogenase (U-LDH) activity and its isozyme patterns in KD.
Total U-LDH activity and its isozymes (U-LDH1-5) levels were compared among 120 patients with KD, 18 patients with viral infection (VI), and 43 patients with upper urinary tract infection (UTI) and additionally compared between intravenous immunoglobulin (IVIG) responders ( n = 89 ) and nonresponders ( n = 31 ) with KD.
Total U-LDH activity was higher in KD ( 35.4 ± 4.8 IU/L, P < 0.05 ) and UTI patients ( 66.0 ± 8.0 IU/L, P < 0.01 ) than in VI patients ( 17.0 ± 6.2 IU/L).
In the isozyme pattern analysis, KD patients had high levels of U-LDH1 and U-LDH2, while UTI patients had high levels of U-LDH3, U-LDH4, and U-LDH5.
Furthermore, IVIG nonresponders of KD had significantly higher levels of total U-LDH activity ( 45.1 ± 4.7 IU/L, P < 0.05 ), especially U-LDH1 and U-LDH2 ( P < 0.05 ), than IVIG responders ( 32.0 ± 2.8 IU/L).
KD patients have increased levels of total U-LDH activity, especially U-LDH-1 and U-LDH2, indicating a unique pattern of U-LDH isozymes different from that in UTI patients.
American Psychological Association (APA)
Kawamura, Yoichi& Takeshita, Seiichiro& Kanai, Takashi& Takizawa, Mari& Yoshida, Yusuke& Tsujita, Yuki…[et al.]. 2017. Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease. International Journal of Pediatrics،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1168678
Modern Language Association (MLA)
Kawamura, Yoichi…[et al.]. Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease. International Journal of Pediatrics No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1168678
American Medical Association (AMA)
Kawamura, Yoichi& Takeshita, Seiichiro& Kanai, Takashi& Takizawa, Mari& Yoshida, Yusuke& Tsujita, Yuki…[et al.]. Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease. International Journal of Pediatrics. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1168678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168678