Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries
Joint Authors
Bijani, Ali
Bijani, Mansoureh
Mostafazadeh, Amrollah
Motallebnejad, Mina
Pourbagher, Roghiyeh
Gharekhani, Samaneh
Source
International Journal of Dentistry
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim and Background.
Early childhood caries (ECC) is a common type of dental caries affecting children.
As dental caries is a bacterial infectious disease, the host immune system parameters including soluble human leukocyte antigen-G (sHLA-G) are essential factors in estimating dental caries.
The study aimed to investigate and compare the concentration of sHLA-G in the saliva of children with or without dental caries.
Methods and Materials.
This analytic cross-sectional study was carried out on 83 healthy children aged 3 to 5 years of both genders, who were divided into three groups based on decayed dental surfaces (ds): group 1, caries-free children (CF, n = 29); group 2, children with 1 ≤ ds ≤ 3, 1 ≤ ds ≤ 4, and 1 ≤ ds ≤ 5 for age 3, 4, and 5 years, respectively (ECC, n = 20); and group 3, children with ds ≥ 4, ds ≥ 5, and ds ≥ 6 for age 3, 4, and 5 years, respectively (S-ECC, n = 34).
The unstimulated saliva samples were collected, and the salivary sHLA-G concentration was measured by the ELISA kit.
The SPSS Statistics v17.0 software and Mann–Whitney, Kruskal–Wallis, chi-square, and Spearman’s rank correlation tests were used for statistical analysis.
The level of significance was considered at p<0.05.
Results.
The mean concentrations of salivary sHLA-G in CF, ECC, and S-ECC groups were 3.18 ± 2.28, 5.64 ± 5.51, and 6.21 ± 6.03 ng/l, respectively (p=0.047), and the mean salivary sHLA-G level was comparatively higher in children with dental caries than that of the CF group (p=0.02), but there is no significant difference between ECC and S-ECC groups (p>0.05).
Spearman’s rank correlation test showed a weak positive correlation (p=0.039, r = 0.22), between the level of salivary sHLA-G and dental caries.
Conclusion.
The present study provides some preliminary evidences on relationship between sHLA-G and dental caries in children.
American Psychological Association (APA)
Bijani, Mansoureh& Mostafazadeh, Amrollah& Motallebnejad, Mina& Bijani, Ali& Pourbagher, Roghiyeh& Gharekhani, Samaneh. 2020. Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries. International Journal of Dentistry،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1169808
Modern Language Association (MLA)
Bijani, Mansoureh…[et al.]. Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries. International Journal of Dentistry No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1169808
American Medical Association (AMA)
Bijani, Mansoureh& Mostafazadeh, Amrollah& Motallebnejad, Mina& Bijani, Ali& Pourbagher, Roghiyeh& Gharekhani, Samaneh. Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries. International Journal of Dentistry. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1169808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169808