Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?
Joint Authors
Bolton, Damien M.
Sethi, Kapil
Rao, Kenny
Patel, Oneel
Ischia, Joseph
Source
International Journal of Cell Biology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Partial nephrectomy (open or minimally invasive) usually requires temporary renal arterial occlusion to limit intraoperative bleeding and improve access to intrarenal structures.
This is a time-critical step due to the critical ischemia period of renal tissue.
Prolonged renal ischemia may lead to irreversible nephron damage in the remaining tissue and, ultimately, chronic kidney disease.
This is potentiated by the incompletely understood ischemia-reperfusion injury (IRI).
A key mechanism in IRI prevention appears to be the upregulation of an intracellular transcription protein, Hypoxia-Inducible Factor (HIF).
HIF mediates metabolic adaptation, angiogenesis, erythropoiesis, cell growth, survival, and apoptosis.
Upregulating HIF-1α via ischemic preconditioning (IPC) or drugs that simulate hypoxia (hypoxia-mimetics) has been investigated as a method to reduce IRI.
While many promising chemical agents have been trialed for the prevention of IRI in small animal studies, all have failed in human trials.
The aim of this review is to highlight the techniques and drugs that target HIF-1α and ameliorate IRI associated with renal ischemia.
Developing a technique or drug that could reduce the risk of acute kidney injury associated with renal IRI would have an immediate worldwide impact on multisystem surgeries that would otherwise risk ischemic tissue injury.
American Psychological Association (APA)
Sethi, Kapil& Rao, Kenny& Bolton, Damien M.& Patel, Oneel& Ischia, Joseph. 2018. Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?. International Journal of Cell Biology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1170016
Modern Language Association (MLA)
Sethi, Kapil…[et al.]. Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?. International Journal of Cell Biology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1170016
American Medical Association (AMA)
Sethi, Kapil& Rao, Kenny& Bolton, Damien M.& Patel, Oneel& Ischia, Joseph. Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?. International Journal of Cell Biology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1170016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170016