Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue
Joint Authors
Sato, Yasufumi
Takeda, Eichi
Suzuki, Yasuhiro
Katagiri, Hideki
Yamada, Tetsuya
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-06
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Vasohibin-1 (Vash1), originally isolated as an endothelium-derived angiogenesis inhibitor, has a characteristic of promoting stress tolerance in endothelial cells (ECs).
We therefore speculated that the lack of the vash1 gene would result in a short lifespan.
However, to our surprise, vash1−/− mice lived significantly longer with a milder senescence phenotype than wild-type (WT) mice.
We sought the cause of this healthy longevity and found that vash1−/− mice exhibited mild insulin resistance along with reduced expression of the insulin receptor (insr), insulin receptor substrate 1 (irs-1), and insulin receptor substrate 2 (irs-2) in their white adipose tissue (WAT) but not in their liver or skeletal muscle.
The expression of vash1 dominated in the WAT among those 3 organs.
Importantly, vash1−/− mice did not develop diabetes even when fed a high-fat diet.
These results indicate that the expression of vash1 was required for the normal insulin sensitivity of the WAT and that the target molecules for this activity were insr, irs1, and irs2.
The lack of vash1 caused mild insulin resistance without the outbreak of overt diabetes and might contribute to healthy longevity.
American Psychological Association (APA)
Takeda, Eichi& Suzuki, Yasuhiro& Yamada, Tetsuya& Katagiri, Hideki& Sato, Yasufumi. 2017. Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue. Journal of Aging Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1170434
Modern Language Association (MLA)
Takeda, Eichi…[et al.]. Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue. Journal of Aging Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1170434
American Medical Association (AMA)
Takeda, Eichi& Suzuki, Yasuhiro& Yamada, Tetsuya& Katagiri, Hideki& Sato, Yasufumi. Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue. Journal of Aging Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1170434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170434