Effects of L-N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients
Joint Authors
Yagi, Shusuke
Kawabata, Yutaka
Soeki, Takeshi
Matsuura, Tomomi
Kusunose, Kenya
Ise, Takayuki
Yamaguchi, Koji
Tobiume, Takeshi
Fukuda, Daiju
Yamada, Hirotsugu
Wakatsuki, Tetsuzo
Kitani, Mitsuhiro
Kawano, Kazuhiro
Taketani, Yoshio
Ito, Hiroyuki
Sata, Masataka
Source
International Journal of Hypertension
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin system (RAS).
In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing the RAS.
Methods.
A total of 25 hypertensive patients receiving a RAS inhibitor were randomly assigned to a cilnidipine (n = 12) or amlodipine (n = 13) group.
The effects of cilnidipine on proteinuria and angiotensin II–renin feedback were assessed.
Results.
After 6 months of treatment, both systolic and diastolic blood pressures were significantly reduced to a similar extent in both groups.
The urine albumin-to-creatinine ratio was significantly lower in the cilnidipine group (p<0.05) than in the amlodipine group.
Amlodipine increased plasma angiotensin I and angiotensin II levels (p<0.05), whereas cilnidipine did not.
Interestingly, the cilnidipine group had a higher ratio of angiotensin-(1–7) (Ang-(1–7)) to angiotensin II in plasma than the amlodipine group (p<0.05).
Conclusions.
The L-/N-type CCB cilnidipine, but not amlodipine, decreased urinary albumin excretion in hypertensive patients.
Cilnidipine also increased the ratio of Ang-(1–7) to angiotensin II in plasma, which might be one factor underlying its beneficial effects.
American Psychological Association (APA)
Kawabata, Yutaka& Soeki, Takeshi& Ito, Hiroyuki& Matsuura, Tomomi& Kusunose, Kenya& Ise, Takayuki…[et al.]. 2020. Effects of L-N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171729
Modern Language Association (MLA)
Kawabata, Yutaka…[et al.]. Effects of L-N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients. International Journal of Hypertension No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1171729
American Medical Association (AMA)
Kawabata, Yutaka& Soeki, Takeshi& Ito, Hiroyuki& Matsuura, Tomomi& Kusunose, Kenya& Ise, Takayuki…[et al.]. Effects of L-N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171729