Effects of L-N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients

Joint Authors

Yagi, Shusuke
Kawabata, Yutaka
Soeki, Takeshi
Matsuura, Tomomi
Kusunose, Kenya
Ise, Takayuki
Yamaguchi, Koji
Tobiume, Takeshi
Fukuda, Daiju
Yamada, Hirotsugu
Wakatsuki, Tetsuzo
Kitani, Mitsuhiro
Kawano, Kazuhiro
Taketani, Yoshio
Ito, Hiroyuki
Sata, Masataka

Source

International Journal of Hypertension

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-22

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases
Medicine

Abstract EN

Objectives.

Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin system (RAS).

In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing the RAS.

Methods.

A total of 25 hypertensive patients receiving a RAS inhibitor were randomly assigned to a cilnidipine (n = 12) or amlodipine (n = 13) group.

The effects of cilnidipine on proteinuria and angiotensin II–renin feedback were assessed.

Results.

After 6 months of treatment, both systolic and diastolic blood pressures were significantly reduced to a similar extent in both groups.

The urine albumin-to-creatinine ratio was significantly lower in the cilnidipine group (p<0.05) than in the amlodipine group.

Amlodipine increased plasma angiotensin I and angiotensin II levels (p<0.05), whereas cilnidipine did not.

Interestingly, the cilnidipine group had a higher ratio of angiotensin-(1–7) (Ang-(1–7)) to angiotensin II in plasma than the amlodipine group (p<0.05).

Conclusions.

The L-/N-type CCB cilnidipine, but not amlodipine, decreased urinary albumin excretion in hypertensive patients.

Cilnidipine also increased the ratio of Ang-(1–7) to angiotensin II in plasma, which might be one factor underlying its beneficial effects.

American Psychological Association (APA)

Kawabata, Yutaka& Soeki, Takeshi& Ito, Hiroyuki& Matsuura, Tomomi& Kusunose, Kenya& Ise, Takayuki…[et al.]. 2020. Effects of L-N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171729

Modern Language Association (MLA)

Kawabata, Yutaka…[et al.]. Effects of L-N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients. International Journal of Hypertension No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1171729

American Medical Association (AMA)

Kawabata, Yutaka& Soeki, Takeshi& Ito, Hiroyuki& Matsuura, Tomomi& Kusunose, Kenya& Ise, Takayuki…[et al.]. Effects of L-N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171729

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1171729