Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones
Joint Authors
Nam, Nguyen Hai
Do, Thi Thao
Vu, Vu Van
Nhung, Trinh Thi
Thanh, Nguyen Thi
Chinh, Luu Van
Tien, Vu Dinh
Thuy, Vu Thu
Koeckritz, Angela
Vu, Tran Khac
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A series of 14 new (-)-gossypol Schiff bases and hydrazones have been synthesized via an in situ procedure in high yields.
Structural data showed that all target compounds exist as the enamine tautomer.
Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines.
Compound 8a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC50 values of 20.93, 13.58, and 9.40 μM, respectively.
However, in an antibacterial test, compounds 8a and 8b inhibited Staphylococcus aureus and Bacillus cereus and compound 8e inhibited only Staphylococcus aureus at the same MIC values of 1024 μg/ml.
American Psychological Association (APA)
Vu, Vu Van& Nhung, Trinh Thi& Thanh, Nguyen Thi& Chinh, Luu Van& Tien, Vu Dinh& Thuy, Vu Thu…[et al.]. 2017. Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1171746
Modern Language Association (MLA)
Vu, Vu Van…[et al.]. Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones. Journal of Chemistry No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1171746
American Medical Association (AMA)
Vu, Vu Van& Nhung, Trinh Thi& Thanh, Nguyen Thi& Chinh, Luu Van& Tien, Vu Dinh& Thuy, Vu Thu…[et al.]. Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1171746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171746