Long-Term Prognosis of Hyperferritinemia Induced by Intravenous Iron Therapy in Patients Undergoing Maintenance Hemodialysis: A 10-Year, Single-Center Study
Joint Authors
Maeda, Sayako
Konishi, Ryo
Morinishi, Takuya
Shimizu, Yoko
Nishio, Haruomi
Takaori, Koji
Source
International Journal of Nephrology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Optimal ferritin level in hemodialysis patients between Japan and other countries is controversial.
Long-term side effects of iron supplementation in these patients remain unclear.
We aimed to elucidate whether past hyperferritinemia in hemodialysis patients was associated with high risk of death and cerebrovascular and cardiovascular diseases (CCVDs).
This small retrospective cohort study included approximately 44 patients unintentionally supplemented with excessive intravenous iron.
A significantly higher risk of CCVDs was observed in patients with initial serum ferritin levels ≥1000 ng/mL than in the remaining patients.
High ferritin levels slowly decreased to <300 ng/mL in a median of 24.2 (10.5–46.5) months without treatment.
However, compared with the remaining patients, only patients whose ferritin levels did not decrease to <300 ng/mL steadily had a significantly higher risk of all-cause death (hazard ratio, 9.6).
Long-term hyperferritinemia due to intravenous iron therapy is a risk factor for death in maintenance hemodialysis patients.
For a prolonged better prognosis, intravenous iron should be carefully administered so as to avoid hyperferritinemia in patients with hemodialysis.
American Psychological Association (APA)
Maeda, Sayako& Konishi, Ryo& Morinishi, Takuya& Shimizu, Yoko& Nishio, Haruomi& Takaori, Koji. 2020. Long-Term Prognosis of Hyperferritinemia Induced by Intravenous Iron Therapy in Patients Undergoing Maintenance Hemodialysis: A 10-Year, Single-Center Study. International Journal of Nephrology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1172812
Modern Language Association (MLA)
Maeda, Sayako…[et al.]. Long-Term Prognosis of Hyperferritinemia Induced by Intravenous Iron Therapy in Patients Undergoing Maintenance Hemodialysis: A 10-Year, Single-Center Study. International Journal of Nephrology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1172812
American Medical Association (AMA)
Maeda, Sayako& Konishi, Ryo& Morinishi, Takuya& Shimizu, Yoko& Nishio, Haruomi& Takaori, Koji. Long-Term Prognosis of Hyperferritinemia Induced by Intravenous Iron Therapy in Patients Undergoing Maintenance Hemodialysis: A 10-Year, Single-Center Study. International Journal of Nephrology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1172812
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172812