Different Analysis of β-Cell Dysfunction as Fasting Glucose Progresses in Obese and Nonobese Newly Diagnosed Type 2 Diabetic Patients
Joint Authors
Liu, Jia
Wang, Guang
Duan, Yan
Sun, Xiaomeng
Fu, Jing
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims/Introduction.
This study is aimed at (1) investigating the change of β-cell dysfunction as baseline fasting glucose progresses in newly diagnosed patients with T2DM and (2) finding whether body mass index (BMI) has different degrees of impact on insulin secretion as baseline fasting glucose progresses.
Materials and Methods.
661 patients with newly diagnosed T2DM were enrolled in the present study.
A 75 g oral glucose tolerance test was used to calculate HOMA-β, HOMA-IR, early-phase insulin secretion index (EISI, calculated as ΔI30/ΔG30), and area under the insulin releasing curve (AUCI0-180).
Patients were divided into low, medium, and high FBG groups.
Each group was further divided into lean, overweight, and obese subgroups according to BMI.
Results.
A decrease of EISI and HOMA-β and an increase of HOMA-IR were shown among different FBG groups significantly.
In the medium FBG group, AUCI0-180, EISI, HOMA-β, and HOMA-IR in obese patients were higher than those in lean and overweight patients.
In the low and high FBG groups, AUCI0-180, HOMA-β, and HOMA-IR in obese patients were higher than those in other subgroups.
BMI was positively associated with high EISI in the medium FBG group but failed to yield a significant association with EISI in the low and high FBG groups.
Conclusions.
During the progression of baseline FBG, β-cell dysfunction and insulin resistance worsened.
As FBG increased, increased BMI had a positive influence on β-cell dysfunction in all FBG groups.
The independent factors that correlated to EISI differed with the increasing of baseline FBG.
American Psychological Association (APA)
Duan, Yan& Sun, Xiaomeng& Liu, Jia& Fu, Jing& Wang, Guang. 2019. Different Analysis of β-Cell Dysfunction as Fasting Glucose Progresses in Obese and Nonobese Newly Diagnosed Type 2 Diabetic Patients. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1173090
Modern Language Association (MLA)
Duan, Yan…[et al.]. Different Analysis of β-Cell Dysfunction as Fasting Glucose Progresses in Obese and Nonobese Newly Diagnosed Type 2 Diabetic Patients. Journal of Diabetes Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1173090
American Medical Association (AMA)
Duan, Yan& Sun, Xiaomeng& Liu, Jia& Fu, Jing& Wang, Guang. Different Analysis of β-Cell Dysfunction as Fasting Glucose Progresses in Obese and Nonobese Newly Diagnosed Type 2 Diabetic Patients. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1173090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173090