Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients
Joint Authors
Duarte, Raquel
Naicker, Saraladevi
Manga, Pravin
Hassan, Muzamil Olamide
Naidoo, Sagren
Vachiat, Ahmed
Grinter, Sacha
Dix-Peek, Thérèse
Dickens, Caroline
Source
International Journal of Nephrology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Transforming growth factor-β (TGF-β) may inhibit the development of atherosclerosis.
We evaluated serum levels of TGF-β isoforms concurrently with serum levels of endotoxin and various inflammatory markers.
In addition, we determined if any association exists between polymorphisms in the TGF-β1 gene and atherosclerosis in South African CKD patients.
Methods.
We studied 120 CKD patients and 40 healthy controls.
Serum TGF-β1, TGF-β2, TGF-β3, endotoxin, and inflammatory markers were measured.
Functional polymorphisms in the TGF-β1 genes were genotyped using a polymerase chain reaction-sequence specific primer method and carotid intima media thickness (CIMT) was assessed by B-mode ultrasonography.
Results.
TGF-β isoforms levels were significantly lower in the patients with atherosclerosis compared to patients without atherosclerosis (p<0.001).
Overall, TGF-β isoforms had inverse relationships with CIMT.
TGF-β1 and TGF-β2 levels were significantly lower in patients with carotid plaque compared to those without carotid plaque [TGF-β1: 31.9 (17.2 – 42.2) versus 45.9 (35.4 – 58.1) ng/ml, p=0.016; and TGF-β2: 1.46 (1.30 – 1.57) versus 1.70 (1.50 – 1.87) ng/ml, p=0.013].
In multiple logistic regression, age, TGF-β2, and TGF-β3 were the only independent predictors of subclinical atherosclerosis in CKD patients [age: odds ratio (OR), 1.054; 95% confidence interval (CI): 1.003 – 1.109, p=0.039; TGF-β2: OR, 0.996; 95% CI: 0.994–0.999, p=0.018; TGF-β3: OR, 0.992; 95% CI: 0.985–0.999, p=0.029).
TGF-β1 genotypes did not influence serum levels of TGF-β1 and no association was found between the TGF-β1 gene polymorphisms and atherosclerosis risk.
Conclusion.
TGF-β isoforms seem to offer protection against the development of atherosclerosis among South African CKD patients.
American Psychological Association (APA)
Hassan, Muzamil Olamide& Duarte, Raquel& Dix-Peek, Thérèse& Dickens, Caroline& Naidoo, Sagren& Vachiat, Ahmed…[et al.]. 2018. Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients. International Journal of Nephrology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1173676
Modern Language Association (MLA)
Hassan, Muzamil Olamide…[et al.]. Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients. International Journal of Nephrology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1173676
American Medical Association (AMA)
Hassan, Muzamil Olamide& Duarte, Raquel& Dix-Peek, Thérèse& Dickens, Caroline& Naidoo, Sagren& Vachiat, Ahmed…[et al.]. Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients. International Journal of Nephrology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1173676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173676