Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population
Joint Authors
Halimi, Jean-Michel
Saulnier, Pierre-Jean
Gand, Elise
Ragot, Stéphanie
Bankir, Lise
Piguel, Xavier
Fumeron, Frédéric
Marechaud, Richard
Roussel, Ronan
Hadjadj, Samy
Study group, SURDIAGENE
Rigalleau, Vincent
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Sodium intake is associated with cardiovascular outcomes.
However, no study has specifically reported an association between cardiovascular mortality and urinary sodium concentration (UNa).
We examined the association of UNa with mortality in a cohort of type 2 diabetes (T2D) patients.
Methods.
Patients were followed for all-cause death and cardiovascular death.
Baseline UNa was measured from second morning spot urinary sample.
We used Cox proportional hazard models to identify independent predictors of mortality.
Improvement in prediction of mortality by the addition of UNa to a model including known risk factors was assessed by the relative integrated discrimination improvement (rIDI) index.
Results.
Participants (n=1,439) were followed for a median of 5.7 years, during which 254 cardiovascular deaths and 429 all-cause deaths were recorded.
UNa independently predicted all-cause and cardiovascular mortality.
An increase of one standard deviation of UNa was associated with a decrease of 21% of all-cause mortality and 22% of cardiovascular mortality.
UNa improved all-cause and cardiovascular mortality prediction beyond identified risk factors (rIDI = 2.8%, P=0.04 and rIDI = 4.6%, P=0.02, resp.).
Conclusions.
In T2D, UNa was an independent predictor of mortality (low concentration is associated with increased risk) and improved modestly its prediction in addition to traditional risk factors.
American Psychological Association (APA)
Saulnier, Pierre-Jean& Gand, Elise& Ragot, Stéphanie& Bankir, Lise& Piguel, Xavier& Fumeron, Frédéric…[et al.]. 2017. Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1174434
Modern Language Association (MLA)
Saulnier, Pierre-Jean…[et al.]. Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population. Journal of Diabetes Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1174434
American Medical Association (AMA)
Saulnier, Pierre-Jean& Gand, Elise& Ragot, Stéphanie& Bankir, Lise& Piguel, Xavier& Fumeron, Frédéric…[et al.]. Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1174434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174434