Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity
Joint Authors
Abdel-Daim, Mohamed M.
Ahmed, Osama M.
El husseny, Mostafa Wanees Ahmed
Mamdouh, Mediana
Shaban, Sara
Ibrahim Abushouk, Abdelrahman
Zaki, Marwa Mostafa Mohamed
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Adipokines are bioactive molecules that regulate several physiological functions such as energy balance, insulin sensitization, appetite regulation, inflammatory response, and vascular homeostasis.
They include proinflammatory cytokines such as adipocyte fatty acid binding protein (A-FABP) and anti-inflammatory cytokines such as adiponectin, as well as vasodilator and vasoconstrictor molecules.
In obesity and type II diabetes mellitus (DM), insulin resistance causes impairment of the endocrine function of the perivascular adipose tissue, an imbalance in the secretion of vasoconstrictor and vasodilator molecules, and an increased production of reactive oxygen species.
Recent studies have shown that targeting plasma levels of adipokines or the expression of their receptors can increase insulin sensitivity, improve vascular function, and reduce the risk of cardiovascular morbidity and mortality.
Several reviews have discussed the potential of adipokines as therapeutic targets for type II DM and obesity; however, this review is the first to focus on their therapeutic potential for vascular dysfunction in type II DM and obesity.
American Psychological Association (APA)
El husseny, Mostafa Wanees Ahmed& Mamdouh, Mediana& Shaban, Sara& Ibrahim Abushouk, Abdelrahman& Zaki, Marwa Mostafa Mohamed& Ahmed, Osama M.…[et al.]. 2017. Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174799
Modern Language Association (MLA)
El husseny, Mostafa Wanees Ahmed…[et al.]. Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity. Journal of Diabetes Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1174799
American Medical Association (AMA)
El husseny, Mostafa Wanees Ahmed& Mamdouh, Mediana& Shaban, Sara& Ibrahim Abushouk, Abdelrahman& Zaki, Marwa Mostafa Mohamed& Ahmed, Osama M.…[et al.]. Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174799