Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization
Joint Authors
Díaz de León Gómez, Ramón Enrique
Saade, Hened
López, Raúl G.
Balleño, J. A.
Mendizábal-Ruiz, A. P.
Rios-Donato, N.
Mendizábal, E.
Source
International Journal of Polymer Science
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ibuprofen-loaded poly(ethyl cyanoacrylate) nanoparticles were prepared by semicontinuous heterophase polymerization of ethyl cyanoacrylate in the presence of ibuprofen; different surfactant concentration, pH, and temperature were used.
Particle size was measured by quasi-light scattering and transmission electron microscopy, while the amount of drug released was determined by UV spectroscopy.
Nanoparticles with diameters between 10 and 58 nm, loaded with ibuprofen, were obtained.
The smallest particles and the higher drug loading were obtained at the highest pH tested.
The analysis of the release data showed that the drug release profiles correspond to the Weibull model.
Moreover, it was found that most of the ibuprofen is released within the first 80–120 min; initially the release rate is slow, but then it increases to finally decrease.
This behavior contrasts with the reported burst of drug concentration in the plasma after oral administration of IB.
American Psychological Association (APA)
Balleño, J. A.& Mendizábal-Ruiz, A. P.& Saade, Hened& Díaz de León Gómez, Ramón Enrique& Mendizábal, E.& Rios-Donato, N.…[et al.]. 2018. Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization. International Journal of Polymer Science،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1175105
Modern Language Association (MLA)
Balleño, J. A.…[et al.]. Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization. International Journal of Polymer Science No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1175105
American Medical Association (AMA)
Balleño, J. A.& Mendizábal-Ruiz, A. P.& Saade, Hened& Díaz de León Gómez, Ramón Enrique& Mendizábal, E.& Rios-Donato, N.…[et al.]. Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization. International Journal of Polymer Science. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1175105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175105