Cutaneous Leishmaniasis: The Complexity of Host’s Effective Immune Response against a Polymorphic Parasitic Disease
Joint Authors
Gabriel, Áurea
Valério-Bolas, Ana
Palma-Marques, Joana
Mourata-Gonçalves, Patrícia
Ruas, Pedro
Dias-Guerreiro, Tatiana
Santos-Gomes, Gabriela
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
This review is aimed at providing a comprehensive outline of the immune response displayed against cutaneous leishmaniasis (CL), the more common zoonotic infection caused by protozoan parasites of the genus Leishmania.
Although of polymorphic clinical presentation, classically CL is characterized by leishmaniotic lesions on the face and extremities of the patients, which can be ulcerative, and even after healing can lead to permanent injuries and disfigurement, affecting significantly their psychological, social, and economic well-being.
According a report released by the World Health Organization, the disability-adjusted life years (DALYs) lost due to leishmaniasis are close to 2.4 million, annually there are 1.0–1.5 million new cases of CL, and a numerous population is at risk in the endemic areas.
Despite its increasing worldwide incidence, it is one of the so-called neglected tropical diseases.
Furthermore, this review provides an overview of the existing knowledge of the host innate and acquired immune response to cutaneous species of Leishmania.
The use of animal models and of in vitro studies has improved the understanding of parasite-host interplay and the complexity of immune mechanisms involved.
The importance of diagnosis accuracy associated with effective patient management in CL reduction is highlighted.
However, the multiple factors involved in CL epizoology associated with the unavailability of vaccines or drugs to prevent infection make difficult to formulate an effective strategy for CL control.
American Psychological Association (APA)
Gabriel, Áurea& Valério-Bolas, Ana& Palma-Marques, Joana& Mourata-Gonçalves, Patrícia& Ruas, Pedro& Dias-Guerreiro, Tatiana…[et al.]. 2019. Cutaneous Leishmaniasis: The Complexity of Host’s Effective Immune Response against a Polymorphic Parasitic Disease. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1175887
Modern Language Association (MLA)
Gabriel, Áurea…[et al.]. Cutaneous Leishmaniasis: The Complexity of Host’s Effective Immune Response against a Polymorphic Parasitic Disease. Journal of Immunology Research No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1175887
American Medical Association (AMA)
Gabriel, Áurea& Valério-Bolas, Ana& Palma-Marques, Joana& Mourata-Gonçalves, Patrícia& Ruas, Pedro& Dias-Guerreiro, Tatiana…[et al.]. Cutaneous Leishmaniasis: The Complexity of Host’s Effective Immune Response against a Polymorphic Parasitic Disease. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1175887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175887