Vesicle-Mediated Dendritic Cell Activation in Acinetobacter baumannii Clinical Isolate, which Contributes to Th2 Response
Joint Authors
Wang, Shengjun
Cai, Wei
Kesavan, Dinesh Kumar
Cheng, Jianjun
Vasudevan, Aparna
Wang, Huixuan
Wan, Jie
Abdelaziz, Mohamed Hamed
Su, Zhaoliang
Xu, Huaxi
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Acinetobacter baumannii, as a nonfermentation Gram-negative bacterium, mainly cause nosocomial infections in critically ill patients.
With the widespread of multidrug-resistant Acinetobacter baumannii, the urgency of developing effective therapy options has been emphasized nowadays.
Outer membrane vesicles derived from bacteria show potential vaccine effects against bacterial infection in recent study.
Our present research is aimed at investigating the mechanisms involved in immune protection of mice after outer membrane vesicle immunization.
As our data showed, the outer membrane vesicle from an Acinetobacter baumannii clinical strain could activate bone marrow-derived dendritic cells (BMDCs) to promote Th2 activity together with humoral immune responses to Acinetobacter baumannii-induced sepsis, which might enlighten people to have a better understanding of OMVs’ role as a vaccine to prevent bacterial infections.
American Psychological Association (APA)
Cai, Wei& Kesavan, Dinesh Kumar& Cheng, Jianjun& Vasudevan, Aparna& Wang, Huixuan& Wan, Jie…[et al.]. 2019. Vesicle-Mediated Dendritic Cell Activation in Acinetobacter baumannii Clinical Isolate, which Contributes to Th2 Response. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1175922
Modern Language Association (MLA)
Cai, Wei…[et al.]. Vesicle-Mediated Dendritic Cell Activation in Acinetobacter baumannii Clinical Isolate, which Contributes to Th2 Response. Journal of Immunology Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1175922
American Medical Association (AMA)
Cai, Wei& Kesavan, Dinesh Kumar& Cheng, Jianjun& Vasudevan, Aparna& Wang, Huixuan& Wan, Jie…[et al.]. Vesicle-Mediated Dendritic Cell Activation in Acinetobacter baumannii Clinical Isolate, which Contributes to Th2 Response. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1175922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175922