A Dynamic Model of PI3KAKT Pathways in Acute Myeloid Leukemia
Joint Authors
Aryati, Lina
Adi-Kusumo, F.
Adi, Yudi Ari
Hardianti, Mardiah S.
Source
Journal of Applied Mathematics
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Acute myeloid leukemia (AML) is a malignant hematopoietic disorder characterized by uncontrolled proliferation of immature myeloid cells.
In the AML cases, the phosphoinositide 3-kinases (PI3K)/AKT signaling pathways are frequently activated and strongly contribute to proliferation and survival of these cells.
In this paper, a mathematical model of the PI3K/AKT signaling pathways in AML is constructed to study the dynamics of the proteins in these pathways.
The model is a 5-dimensional system of the first-order ODE which describes the interaction of the proteins in AML.
The interactions between those components are assumed to follow biochemical reactions, which are modelled by Hill’s equation.
From the numerical simulations, there are three potential components targets in PI3K/AKT pathways to therapy in the treatment of AML patient.
American Psychological Association (APA)
Adi, Yudi Ari& Adi-Kusumo, F.& Aryati, Lina& Hardianti, Mardiah S.. 2018. A Dynamic Model of PI3KAKT Pathways in Acute Myeloid Leukemia. Journal of Applied Mathematics،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1175989
Modern Language Association (MLA)
Adi, Yudi Ari…[et al.]. A Dynamic Model of PI3KAKT Pathways in Acute Myeloid Leukemia. Journal of Applied Mathematics No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1175989
American Medical Association (AMA)
Adi, Yudi Ari& Adi-Kusumo, F.& Aryati, Lina& Hardianti, Mardiah S.. A Dynamic Model of PI3KAKT Pathways in Acute Myeloid Leukemia. Journal of Applied Mathematics. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1175989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175989