Serum Leucine-Rich α2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis
Joint Authors
Yachie, Akihiro
Shimizu, Masaki
Inoue, Natsumi
Mizuta, Mao
Nakagishi, Yasuo
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To investigate whether serum leucine-rich α2-glycoprotein (LRG) levels are useful as a marker of disease activity in systemic juvenile idiopathic arthritis (s-JIA), we determined serum LRG levels in fifty-nine s-JIA patients, 15 with other subtypes of JIA, 7 with Kawasaki disease (KD), 7 with influenza A infection (flu), 7 with enterohemorrhagic Escherichia coli (EHEC) infection, and 20 healthy controls (HC).
Results were compared with the clinical features of s-JIA and serum cytokine levels including interleukin- (IL-) 6, IL-18, and soluble tumor necrosis factor receptors I and II.
Serum LRG levels in active s-JIA were higher compared to those in other subtypes of JIA, EHEC, flu patients, and HC.
Serum LRG levels were normalized in the inactive s-JIA phase after treatment.
Serum LRG levels were positively correlated with serum C-reactive protein and ferritin levels.
Serum LRG levels reflected s-JIA disease activity and thus may be useful for monitoring s-JIA disease activity.
American Psychological Association (APA)
Shimizu, Masaki& Inoue, Natsumi& Mizuta, Mao& Nakagishi, Yasuo& Yachie, Akihiro. 2019. Serum Leucine-Rich α2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1176028
Modern Language Association (MLA)
Shimizu, Masaki…[et al.]. Serum Leucine-Rich α2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis. Journal of Immunology Research No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1176028
American Medical Association (AMA)
Shimizu, Masaki& Inoue, Natsumi& Mizuta, Mao& Nakagishi, Yasuo& Yachie, Akihiro. Serum Leucine-Rich α2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1176028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176028